3-(difluoromethyl)thiophene-2-carboxylic acid CAS 189330-25-4
| CAS No. | 189330-25-4 |
| Molecular Formula | C6H8F2O2S |
| Molecular Weight | 182.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(difluoromethyl)thiophene-2-carboxylic acid is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(difluoromethyl)thiophene-2-carboxylic acid (CAS 189330-25-4) is a high-purity analytical reference standard with the molecular formula C6H8F2O2S and a molecular weight of 182.19 g/mol.
Based on its molecular formula C6H8F2O2S, 3-(difluoromethyl)thiophene-2-carboxylic acid contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 182.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(difluoromethyl)thiophene-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8F2O2S |
| Molecular Weight | 182.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2011 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related difluoromethyl Standards
- [2-(difluoromethyl)-4-fluoro-phenyl]hydrazine (CAS 1806667-02-6)
- 5-(difluoromethyl)thiophene-2-carboxylic acid (CAS 189330-23-2)
- 1-(difluoromethyl)-1H-indol-4-amine (CAS 1429043-06-0)
- 2-(Difluoromethyl)-3-methylpyridine-4-acetonitrile (CAS 1804443-57-9)
- 2-(Difluoromethyl)-4-methylpyridine-3-acetonitrile (CAS 1805279-54-2)
- 2-(4-(Difluoromethyl)-3-methylpyridin-2-yl)acetonitrile (CAS 1805317-89-8)
- 2-(Difluoromethyl)-5-methylpyridine-3-acetonitrile (CAS 1806069-75-9)
- 2-(Difluoromethyl)-3-methylpyridine-6-acetonitrile (CAS 1806802-78-7)
Recommended Standards
- Methyl 2-(2-fluorophenyl)propanoate (CAS 191351-61-8)
- 1-(2,2,2-Trifluoroethyl)piperidin-4-amine (CAS 187217-99-8)
- 3-Fluoro-4-propoxybenzaldehyde (CAS 19415-48-6)
- methyl 3-fluoro-2-phenylpropanoate (CAS 186700-31-2)
- 207619-48-5 (1-Methyl-1H-indol-3-yl)(piperidino)methanone MFCD04126332 (CAS 207619-48-5)
- 3,3,3-Trifluoro-2-hydroxy-2-(trifluoromethyl)propanenitrile (CAS 677-77-0)
- (2-Mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl)methanol (CAS 470690-99-4)
- n-(3-(3,5-Dimethyl-1h-pyrazol-1-yl)propyl)furan-2-carboxamide (CAS 1017981-43-9)
- Ethyl 4-((3-(2-hydroxy-4-methoxyphenyl)-1H-pyrazol-4-yl)oxy)benzoate (CAS 1010869-14-3)
- 4-Chloro-3,5-bis-trifluoromethyl-pyridine (CAS 1286743-85-8)
- (R)-2-Amino-2-(3-chlorophenyl)ethanol (CAS 926291-77-2)
- Ethyl 2-(3-bromo-4-chlorophenyl)acetate (CAS 1208076-13-4)
- 2-[2-(propan-2-yl)-1H,2H,3H,4H,5H-pyrido[4,3-b]indol-5-yl]acetic acid hydrochloride (CAS 1798760-53-8)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
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