1,4-Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine CAS 190437-62-8
| CAS No. | 190437-62-8 |
| Molecular Formula | C16H12Cl2F6N4 |
| Molecular Weight | 445.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1,4-Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine.
1,4-Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine (CAS 190437-62-8) is a high-purity analytical reference standard with the molecular formula C16H12Cl2F6N4 and a molecular weight of 445.19 g/mol.
Based on its molecular formula C16H12Cl2F6N4, 1,4-Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 445.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2F6N4 |
| Molecular Weight | 445.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Bis Standards
- 3-[(1E)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-2-cyanoeth-1-en-1-yl]-1-(4-chlorophenyl)urea (CAS 337920-11-3)
- Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,2,5-oxadiazol-2-ium-2-olate (CAS 303997-49-1)
- 3-Chloro-4-pyridylcycloheptyl ketone (CAS 898785-24-5)
- 3-[1-(2-Chloro-4-fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775365-93-9)
- 3-[1-(3-Chloro-4-fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775516-32-9)
- 3-[1-(5-Chloro-2-fluorobenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775525-66-0)
- 3-[1-(4-Chloro-2-methoxybenzoyl)piperidin-4-yl]-4-[(4-fluorophenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775536-13-4)
- 2-{[2-(5-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}thiophen-2-yl)-2-oxoethyl]sulfanyl}pyridin-1-ium-1-olate (CAS 339016-51-2)
Recommended Standards
- 3-Fluoro-6-isobutoxy-2,4-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (CAS 2377606-11-4)
- 6,8-Dibromo-2-(4-cyclohexylphenyl)quinoline (CAS 866040-62-2)
- (S)-ethyl 2-(2,6-dichlorobenzamido)-3-(4-bromophenyl)propanoate (CAS 232276-01-6)
- N,N-Bis(4-bromophenyl)-2,4,6-trimethylaniline (CAS 663943-27-9)
- 2-Chloro-6-methoxypyridine-3-carbonyl chloride (CAS 1073230-28-0)
- 3-(1h-Pyrrol-1-yl)aniline (CAS 89353-42-4)
- 6-(3,4-Dihydroquinolin-1(2H)-yl)-4-methylnicotinic acid (CAS 1355200-27-9)
- 3-((1-Methyl-1H-pyrazol-4-yl)amino)thietane 1,1-dioxide (CAS 1864546-73-5)
- 3-(4-Ethylbenzylidene)-4,5,6,7-tetraphenylisobenzofuran-1(3H)-one (CAS 52986-59-1)
- 3-[4-(4-methoxyphenyl)piperazin-1-yl]propan-1-amine (CAS 40255-50-3)
- (3-((6-(2-Methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methanesulfonamide (CAS 1073485-20-7)
- 6-Chloro-2-(4-chlorophenyl)quinoline-4-carbohydrazide (CAS 590360-17-1)
- 5-Hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-chromen-7-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside (CAS 53840-60-1)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com