(3S)-Tryptophan EP Impurity I (Mixture of Diastereomers) CAS 191279-37-5
| CAS No. | 191279-37-5 |
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies (3S)-Tryptophan EP Impurity I (Mixture of Diastereomers) (CAS 191279-37-5), a pharmacopoeial impurity reference standard (molecular formula C13H14N2O2, MW 230.26 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of (3S)-Tryptophan EP Impurity I (Mixture of Diastereomers) (C13H14N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Nitrogen Atoms | 2 |
Related S Standards
- (3R)-Tryptophan EP Impurity I (Mixture of Diastereomers) (CAS 827304-63-2)
- Tryptophan EP Impurity I (CAS 5470-37-1)
- Tryptophan Cyclized Impurity (CAS 40856-80-2)
- Tryptophan Impurity 18 (CAS 25198-03-2)
- Tryptophan Impurity 7 (CAS 13081-15-7)
- Tryptophan Impurity 16 (CAS CATO-C4X-137316)
- Tryptophan EP Impurity B (Mixture of Diastereomers) (CAS 184955-21-3)
- Tryptophan impurity 38 (Mixture of Diastereomers) (CAS CATO-C4X-137338)
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