Tryptophan EP Impurity I CAS 5470-37-1
| CAS No. | 5470-37-1 |
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Tryptophan EP Impurity I (CAS 5470-37-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14N2O2 and a molecular weight of 230.26 g/mol.
Based on its molecular formula C13H14N2O2, Tryptophan EP Impurity I contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 230.26 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Tryptophan EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14N2O2 |
| Molecular Weight | 230.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 2 |
Related Tryptophan Standards
- (3S)-Tryptophan EP Impurity I (Mixture of Diastereomers) (CAS 191279-37-5)
- (3R)-Tryptophan EP Impurity I (Mixture of Diastereomers) (CAS 827304-63-2)
- Tryptophan Cyclized Impurity (CAS 40856-80-2)
- Tryptophan Impurity 18 (CAS 25198-03-2)
- Tryptophan Impurity 7 (CAS 13081-15-7)
- Tryptophan Impurity 16 (CAS CATO-C4X-137316)
- Tryptophan EP Impurity B (Mixture of Diastereomers) (CAS 184955-21-3)
- Tryptophan impurity 38 (Mixture of Diastereomers) (CAS CATO-C4X-137338)
Recommended Standards
- Bisoprolol Impurity 93 (CAS 2350-43-8)
- Naproxen Impurity 26 (CAS 23981-80-8)
- Bisoprolol Impurity 56 (CAS 145059-66-1)
- Naproxen EP Impurity G (R-Naproxen) (CAS 23979-41-1)
- Guaifenesin Impurity 7 (CAS 120-80-9)
- Levalbuterol Impurity 2 (CAS CATO-C4X-22592)
- Peramivir Impurity 19 (CAS 1591861-50-5)
- 2-(Difluoromethyl)-4-iodo-3-nitropyridine-5-carboxylic acid (CAS 1805510-61-5)
- 1-(1-(4-Fluorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-ol (CAS 1443291-24-4)
- 2-Ethoxy-4-(4-methoxyphenyl)furan (CAS 155108-62-6)
- 2-Bromo-5-(2,2,2-trifluoroethyl)-1,3,4-thiadiazole (CAS 1339415-01-8)
- 2-(2-(2H-chromen-3-yl)thiazol-4-yl)acetic acid (CAS 1291490-26-0)
- 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid (CAS 4364-02-7)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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