Dolutegravir Impurity 19 CAS 1916490-96-4
| CAS No. | 1916490-96-4 |
| Molecular Formula | C14H9F4N |
| Molecular Weight | 267.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dolutegravir Impurity 19 (CAS 1916490-96-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H9F4N and a molecular weight of 267.22 g/mol.
Structurally, Dolutegravir Impurity 19 (C14H9F4N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 267.22 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dolutegravir Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9F4N |
| Molecular Weight | 267.22 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Dolutegravir Standards
- Dolutegravir Impurity 27 (CAS 1335210-31-5)
- Dolutegravir Amide (CAS 1485081-26-2)
- Dolutegravir Impurity 67 (CAS CATO-C4X-162067)
- Dolutegravir Impurity N13 (CAS 1246616-73-8)
- Dolutegravir Impurity 51 (CAS CATO-C4X-162051)
- Dolutegravir Impurity 43 (CAS 2651309-06-5)
- Dolutegravir Impurity N1 (CAS 1335210-34-8)
- Dolutegravir Impurity 24 (CAS 2315439-81-5)
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