Pomalidomide Impurity 23 CAS 191732-76-0
| CAS No. | 191732-76-0 |
| Molecular Formula | C13H11N3O4 |
| Molecular Weight | 273.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Pomalidomide Impurity 23 (C13H11N3O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Pomalidomide Impurity 23 (CAS 191732-76-0, C13H11N3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11N3O4 |
| Molecular Weight | 273.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Nitrogen Atoms | 3 |
Related Pomalidomide Standards
- (S)-Pomalidomide (CAS 202271-89-4)
- Pomalidomide (CAS 19171-19-8)
- (R)-Pomalidomide (CAS 202271-90-7)
- Pomalidomide Impurity 15 (CAS 5054-59-1)
- Pomalidomide Related Compound 7 (CAS 835616-60-9)
- Pomalidomide Impurity 19 (CAS 39133-20-5)
- Pomalidomide Impurity 17 (CAS 1377838-49-7)
- Pomalidomide Impurity 22 (CAS 13139-52-1)
Recommended Standards
- Nintedanib Impurity 95 (CAS 16320-52-8)
- Lenalidomide Impurity 19 (CAS CATO-C4X-190319)
- Eltrombopag Impurity 20 (CAS 376591-94-5)
- 14-Bromo-1-tetradecyne (CAS 1000014-24-3)
- Acalabrutinib Impurity 15 (CAS CATO-C4X-305515)
- Ticagrelor impurity 169 (CAS CATO-C4X-1093169)
- Rimegepant Impurity 132 (CAS CATO-C4X-2487132)
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- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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