Eltrombopag Impurity 20 CAS 376591-94-5
| CAS No. | 376591-94-5 |
| Molecular Formula | C14H11NO5 |
| Molecular Weight | 273.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Eltrombopag Impurity 20 (CAS 376591-94-5), a pharmacopoeial impurity reference standard (molecular formula C14H11NO5, MW 273.24 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Eltrombopag Impurity 20 (C14H11NO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 273.24 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Eltrombopag Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11NO5 |
| Molecular Weight | 273.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 109 (CAS CATO-C4X-1198109)
- Eltrombopag Impurity 110 (CAS CATO-C4X-1198110)
- Eltrombopag Impurity 111 (CAS CATO-C4X-1198111)
- Eltrombopag Impurity 112 (CAS CATO-C4X-1198112)
- Eltrombopag Impurity 125 (CAS CATO-C4X-1198125)
- Eltrombopag Impurity 126 (CAS CATO-C4X-1198126)
- Eltrombopag impurity 140 (CAS CATO-C4X-1198140)
- Eltrombopag Impurity 56 (CAS 36324-64-8)
Recommended Standards
- Pomalidomide (CAS 19171-19-8)
- (R)-Pomalidomide (CAS 202271-90-7)
- Pomalidomide Impurity 23 (CAS 191732-76-0)
- Nintedanib Impurity 95 (CAS 16320-52-8)
- Gadodiamide EP Impurity B Disodium Salt (CAS 92923-64-3)
- Isavuconazole Impurity 12 (CAS CATO-C4X-123612)
- Vonoprazan Impurity 263 (CAS CATO-C4X-1020263)
- 5-{4-[(4-fluorophenyl)methoxy]phenyl}-2,3-dihydro-1,3,4-oxadiazol-2-one (CAS 866009-87-2)
- 5-Benzyl-3-(4-chlorophenyl)-1,2,4-oxadiazole (CAS 21614-49-3)
- VS-5584, >98% (HPLC) (CAS 1246560-33-7)
- Empagliflozin Impurity 81 (CAS CATO-C4X-106581)
- 3-Amino-1-[4-(3-methylphenyl)piperazin-1-yl]propan-1-one (CAS 896520-86-8)
- Ubenimex Impurity 9 (CAS CATO-C4X-18529)
- Myristoyl Pentapeptide-4 (CAS 1392416-25-9)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com