Tolvaptan Impurity 6 CAS 193686-76-9
| CAS No. | 193686-76-9 |
| Molecular Formula | C17H16ClNO3S |
| Molecular Weight | 349.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tolvaptan Impurity 6 (CAS 193686-76-9, C17H16ClNO3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tolvaptan Impurity 6 (C17H16ClNO3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H16ClNO3S |
| Molecular Weight | 349.83 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Tolvaptan Standards
- Tolvaptan Impurity 70 (CAS CATO-C4X-195570)
- Tolvaptan Impurity 120 (CAS CATO-C4X-1955120)
- Tolvaptan impurity 113 (CAS CATO-C4X-1955113)
- Tolvaptan Impurity 20 (CAS 137982-91-3)
- Tolvaptan Impurity 1 (CAS 247237-38-3)
- Tolvaptan Impurity 13 (CAS CATO-C4X-195513)
- Tolvaptan Impurity 122 (CAS CATO-C4X-1955122)
- Tolvaptan Impurity 121 (CAS CATO-C4X-1955121)
Recommended Standards
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- 3,3-Dimethyl-4-(methylamino)butan-1-ol hydrochloride (CAS 1427379-38-1)
- 2-(6-Methyl-1h-indol-3-yl)acetonitrile (CAS 500777-89-9)
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- 1-(4-Bromophenyl)-2,2-difluoroethanamine (CAS 843608-52-6)
- Antistasin-Related Peptide (CAS 161561-46-2)
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