Sevoflurane Impurity 4 CAS 194039-81-1
| CAS No. | 194039-81-1 |
| Molecular Formula | C7H4F12O2 |
| Molecular Weight | 348.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sevoflurane Impurity 4.
As a process- or degradation-related impurity, Sevoflurane Impurity 4 (CAS 194039-81-1, C7H4F12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sevoflurane Impurity 4 (C7H4F12O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4F12O2 |
| Molecular Weight | 348.09 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | F-containing |
Related Sevoflurane Standards
- Sevoflurane Impurity 13 (CAS 194039-83-3)
- Sevoflurane Impurity 8 (CAS 79507-76-9)
- Sevoflurane Impurity 11 (CAS 33034-42-3)
- Sevoflurane Impurity 0 (CAS CATO-C4X-25310)
- Sevoflurane Impurity 10 (CAS 32793-53-6)
- Sevoflurane Impurity 5 (CAS 28523-85-5)
- Sevoflurane Impurity 6 (CAS 26103-07-1)
- Sevoflurane Impurity 6 (CAS 58109-33-4)
Recommended Standards
- 2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoroheptane-1,1-diol (CAS 812-87-3)
- 1H,1H,1H,2H,2H-Perfluorooctane (CAS 80793-17-5)
- 2-(5-Bromopyridin-2-yl)-1-(2,4-difluorophenyl)-2,2-difluoroethan-1-one (CAS 294182-06-2)
- Ethyl 3-((4-iodo-1h-pyrazol-1-yl)methyl)-1,2,4-oxadiazole-5-carboxylate (CAS 956263-70-0)
- Finasteride Impurity N89 (CAS 1180488-92-9)
- Sulpiride impurity 17 (CAS CATO-C4X-187617)
- Zolmitriptan Impurity 33 Iodide (Mixture of Diastereomers) (CAS CATO-C4X-135133)
- 1-Chloro-8-fluoro-7-methoxynaphthalen-2-ol (CAS 1447450-00-1)
- 2-Acetyl-3-hydroxyisonicotinic acid (CAS 1393561-62-0)
- 3-Bromo-4,5-dimethylnitrobenzene, 97% (CAS 22162-22-7)
- 2'-Deoxyuridine-5'-triphosphate Trisodium Salt (CAS 102814-08-4)
- 3-Chloro-N-(4-(trifluoromethoxy)phenyl)propanamide (CAS 886498-78-8)
- 1-Benzyl-3,5-dibromobenzene (CAS 71572-36-6)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
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