Brivaracetam Impurity 18 CAS 1942054-60-5
| CAS No. | 1942054-60-5 |
| Molecular Formula | C7H13BrO2 |
| Molecular Weight | 209.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Brivaracetam Impurity 18.
As a process- or degradation-related impurity, Brivaracetam Impurity 18 (CAS 1942054-60-5, C7H13BrO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Brivaracetam Impurity 18 (C7H13BrO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H13BrO2 |
| Molecular Weight | 209.08 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Br-containing |
Related Brivaracetam Standards
- Brivaracetam Impurity 42 (CAS 2101641-92-1)
- Brivaracetam Impurity 67 (CAS 357338-13-7)
- Brivaracetam Impurity 165 (CAS CATO-C4X-2007165)
- Brivaracetam Impurity 197 (CAS CATO-C4X-2007197)
- Brivaracetam (CAS 357336-20-0)
- Brivaracetam impurity 104 (CAS 357334-83-9)
- Brivaracetam Impurity 131 (CAS CATO-C4X-2007131)
- Brivaracetam Impurity 144 (CAS CATO-C4X-2007144)
Recommended Standards
- Amiodarone Impurity 31 (CAS 5445-19-2)
- Choline fenofibrate Impurity 24 (CAS 51368-55-9)
- 2,6-Dichlorophenylmethylsulfoxide (CAS 122199-98-8)
- Ethyl 2-bromoisovalerate (CAS 609-12-1)
- Cholecalciferol Impurity 17 (CAS 1183-41-1)
- Pitolisant impurity 26 (CAS CATO-C4X-252026)
- Fosfomycin Trometamol EP Impurity A (CAS 84954-80-3)
- Methyl-1-naphthalenemethylamine-d3 (CAS 1033720-13-6)
- (1S,2S)-2-(6-Aminopyridin-3-yl)cyclopropane-1-carboxylic acid (CAS 2084048-18-8)
- n-(6-Methylheptan-2-yl)tetrahydro-2h-pyran-4-amine (CAS 1157014-65-7)
- Methyl 4-iodo-6-(trifluoromethyl)nicotinate (CAS 1804441-19-7)
- 6-Amino-5-methoxypicolinic acid (CAS 2089378-10-7)
- 2-Fluoro-N-(2,2,2-trichloro-1-hydroxyethyl)acetamide (CAS 687-01-4)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
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