(4,4-Difluorocyclohexyl)methyl methanesulfonate CAS 194427-24-2
| CAS No. | 194427-24-2 |
| Molecular Formula | C8H14F2O3S |
| Molecular Weight | 228.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
(4,4-Difluorocyclohexyl)methyl methanesulfonate (CAS 194427-24-2) is a high-purity analytical reference standard with the molecular formula C8H14F2O3S and a molecular weight of 228.26 g/mol.
The molecular framework of (4,4-Difluorocyclohexyl)methyl methanesulfonate (C8H14F2O3S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H14F2O3S |
| Molecular Weight | 228.26 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluorocyclohexyl Standards
- (3,3-difluorocyclohexyl)methyl methanesulfonate (CAS 1803598-43-7)
- (4,4-difluorocyclohexyl)methanesulfonyl chloride (CAS 1566537-63-0)
- (3,3-difluorocyclohexyl)methanesulfonyl chloride (CAS 1691933-77-3)
- (2,2-difluorocyclohexyl)methanesulfonyl chloride (CAS 1784380-35-3)
- 2-(4,4-Difluorocyclohexyl)-3-methoxy-3-oxopropanoic acid (CAS 2756337-15-0)
- (1S)-1-(3,3-Difluorocyclohexyl)-2,2,2-trifluoroethan-1-amine (CAS 2791313-77-2)
- 2-(3,3-Difluorocyclohexyl)-2,2-difluoroacetic acid (CAS 1784863-22-4)
- 4-(4,4-Difluorocyclohexyl)phenol (CAS 161553-81-7)
Recommended Standards
- 2-(4-Fluorophenyl)-1-(p-tolyl)ethanone (CAS 191346-50-6)
- (2,4-Dimethylphenyl)(4-fluorophenyl)methanone (CAS 837-61-6)
- 3-((1-(Hydroxymethyl)cyclopropyl)sulfonyl)phenol (CAS 1890023-03-6)
- (2,5-Dimethylphenyl)(2-fluorophenyl)methanone (CAS 2250-60-4)
- (R)-5-Oxo-1,4-thiazepane-3-carboxylic acid (CAS 35082-57-6)
- 2-(1-(Methylsulfonyl)cyclobutyl)thiazole-4-carboxylic acid (CAS 1708289-13-7)
- 2-Fluoro-6-((tetrahydrofuran-2-yl)methoxy)aniline (CAS 1183643-73-3)
- 5-[1-m-Tolyl-meth-(Z)-ylidene]-imidazolidine-2,4-dione (CAS 432001-00-8)
- 3-((5-((4-Aminopiperidin-1-yl)methyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)-5-(2-isopropyl-2H-tetrazol-5-yl)phenol, >98% (HPLC) (CAS 1699861-37-4)
- 7-Methoxybenzo[c]isoxazole (CAS 122528-40-9)
- pyrrolo[2,1-f][1,2,4]triazine-6-carboximidamide (CAS 1557884-29-3)
- N-(4-Nitrophenyl)acrylamide (CAS 7766-38-3)
- 2-(6-Oxo-4-(pyridin-3-yl)pyrimidin-1(6H)-yl)acetic acid (CAS 1708263-95-9)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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