(R)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one CAS 1946010-79-2
| CAS No. | 1946010-79-2 |
| Molecular Formula | C19H21ClF3N5O2 |
| Molecular Weight | 443.85 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one.
(R)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one (CAS 1946010-79-2) is a high-purity analytical reference standard with the molecular formula C19H21ClF3N5O2 and a molecular weight of 443.85 g/mol.
(R)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one (C19H21ClF3N5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H21ClF3N5O2 |
| Molecular Weight | 443.85 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related R Standards
- 1523406-39-4 (S)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one MFCD28411361 (CAS 1523406-39-4)
- N'-(6-Chloropyridin-2-yl)-2,5-bis(2,2,2-trifluoroethoxy)benzohydrazide (CAS 338785-31-2)
- 1,3-Bis((6-chloropyridin-3-yl)methyl)-2-phenyl-1H-indole (CAS 861211-50-9)
- 1-[4-(6-Chloropyridin-2-yl)piperazin-1-yl]-2-(2-phenyladamantan-2-yl)ethan-1-one (CAS 400086-45-5)
- 2-(((6-Chloropyridin-3-yl)methyl)thio)-6-(4-methoxyphenyl)-4-(trifluoromethyl)nicotinonitrile (CAS 664999-86-4)
- N-(2-(5-Chloropyridin-2-yl)ethyl)-4-(((4-methoxyphenyl)sulfonamido)methyl)benzamide (CAS 1943733-16-1)
- 1-((2-((2-Chloropyridin-4-yl)amino)-4'-(cyclopropylmethyl)-[4,5'-bipyrimidin]-2'-yl)amino)-2-methylpropan-2-ol (CAS 1383716-33-3)
- 3-[(1E)-1-[2-(6-Chloropyridin-2-yl)hydrazin-1-yl]-2-(2,4-dichlorophenoxy)ethylidene]-1-phenylurea (CAS 338418-66-9)
Recommended Standards
- (E)-{[2-(4-chlorophenyl)-7-methylimidazo[1,2-a]pyridin-3-yl]methylidene}({[3-(trifluoromethyl)phenyl]methoxy})amine (CAS 478257-49-7)
- 5-Chloro-4-{[(2,3-dichlorophenyl)sulfanyl]methyl}-1-methyl-3-{[(4-methylphenyl)sulfanyl]methyl}-1H-pyrazole (CAS 318248-66-7)
- 2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-4-phenylpyridine-3-carbonitrile (CAS 860650-51-7)
- 5-Chloro-4-(((2,6-dichlorophenyl)thio)methyl)-1-methyl-3-((p-tolylthio)methyl)-1H-pyrazole (CAS 318248-67-8)
- 3,4-dichloro-5-phenyl-2(5H)-furanone (CAS 72857-85-3)
- N-Allyl-N-hydroxypent-4-enamide (CAS 87842-83-9)
- 2,3-dihydrobenzo[b][1,4]oxathiine (CAS 6812-48-2)
- methyl 5-bromo-6-oxo-1H-pyrazine-3-carboxylate (CAS 1017603-85-8)
- tert-Butyl2-(cyanomethyl)pyrrolidine-1-carboxylate (CAS 1092352-11-8)
- 4-(Cyclopropylmethyl)piperidine-4-carbonitrile (CAS 882035-12-3)
- 4-(Cyclohexylamino)butanenitrile (CAS 1020957-41-8)
- (3-Fluoro-5-(1H-imidazol-1-yl)phenyl)boronic acid (CAS 2225155-88-2)
- 2,2-Dimethyl-5-{[6-(4-methylphenyl)imidazo[2,1-b][1,3]thiazol-5-yl]methylidene}-1,3-dioxane-4,6-dione (CAS 439107-31-0)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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