Semaglutide Impurity 246 CAS CATO-C4X-2226246
| CAS No. | CATO-C4X-2226246 |
| Molecular Formula | C28H46N12O8 |
| Molecular Weight | 678.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Semaglutide Impurity 246 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Semaglutide Impurity 246 (CAS CATO-C4X-2226246) is a certified pharmaceutical impurity reference standard with the molecular formula C28H46N12O8 and a molecular weight of 678.74 g/mol.
The molecular framework of Semaglutide Impurity 246 (C28H46N12O8) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Semaglutide Impurity 246 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H46N12O8 |
| Molecular Weight | 678.74 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 12 |
Related Semaglutide Standards
- Semaglutide impurity 244(Fmoc-His(Fmoc)-Aib-OH) (CAS CATO-C4X-2226244)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
- Semaglutide impurity 69 (CAS CATO-C4X-222669)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
- Semaglutide Impurity 18 (CAS 1671100-14-3)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
- Semaglutide impurity 237 (CAS CATO-C4X-2226237)
Recommended Standards
- diABZI STING Agonist-2 (CAS 2138300-40-8)
- 4,4'-Bis(4-amino-1-naphthylazo)-2,2'-stilbenedisulfonic Acid (CAS 5463-64-9)
- N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(3,7-dioxo-1,9-diphenyl-2,8-dioxa-4,6-diazanonan-5-ylidene)lysine (CAS 2044709-94-4)
- 17β-Estradiol 3-O-Benzyl 17-(2,3,4-Tri-O-acetyl-β-D-glucuronide Methyl Ester) (CAS 14364-98-8)
- Oxybutynin Impurity 13 (CAS CATO-C4X-197213)
- Argatroban Impurity 13 (CAS 94975-84-5)
- Semaglutide impurity 68 (CAS CATO-C4X-222668)
- 4-(tert-Butyl) 2-methyl (R)-morpholine-2,4-dicarboxylate (CAS 1932348-85-0)
- H-Met-Arg-OH (CAS 60461-10-1)
- 5-Nitro-1H-pyrrole-2-carbaldehyde (CAS 6327-67-9)
- 7-Fluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (CAS 911485-90-0)
- 2-Amino-5-(aminomethyl)-6-(difluoromethyl)pyridin-3-ol (CAS 1805951-83-0)
- 3-Cyclopropyl-1-phenyl-1H-pyrazole-5-carboxylic acid (CAS 890593-19-8)
- D-Thr7-Tirzepatide (CAS CATO-CPTD788924)
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