Ceftolozane impurity 5 CAS 1956303-48-2
| CAS No. | 1956303-48-2 |
| Molecular Formula | C8H11N5O4S |
| Molecular Weight | 273.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ceftolozane impurity 5 (C8H11N5O4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Ceftolozane impurity 5 (CAS 1956303-48-2, C8H11N5O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11N5O4S |
| Molecular Weight | 273.27 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Ceftolozane Standards
- Ceftolozane Impurity 11 (CAS CATO-C4X-240611)
- Ceftolozane impurity 46 (CAS CATO-C4X-240646)
- Ceftolozane Impurity N2 (CAS 116856-12-3)
- Ceftolozane Impurity 37 (CAS CATO-C4X-240637)
- Ceftolozane Impurity 12 (CAS CATO-C4X-240612)
- Ceftolozane impurity 45 (CAS CATO-C4X-240645)
- Ceftolozane Impurity 38 (CAS CATO-C4X-240638)
- Ceftolozane Impurity 13 (CAS CATO-C4X-240613)
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