Ceftolozane impurity 45 CAS CATO-C4X-240645
| CAS No. | CATO-C4X-240645 |
| Molecular Formula | C12H21N3O5 |
| Molecular Weight | 287.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ceftolozane impurity 45.
CATO supplies Ceftolozane impurity 45 (CAS CATO-C4X-240645), a pharmacopoeial impurity reference standard (molecular formula C12H21N3O5, MW 287.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Ceftolozane impurity 45 (C12H21N3O5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ceftolozane impurity 45 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H21N3O5 |
| Molecular Weight | 287.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
Related Ceftolozane Standards
- Ceftolozane Impurity 38 (CAS CATO-C4X-240638)
- Ceftolozane Impurity 12 (CAS CATO-C4X-240612)
- Ceftolozane Impurity N2 (CAS 116856-12-3)
- Ceftolozane Impurity 11 (CAS CATO-C4X-240611)
- Ceftolozane impurity 46 (CAS CATO-C4X-240646)
- Ceftolozane impurity 5 (CAS 1956303-48-2)
- Ceftolozane Impurity 39 (CAS CATO-C4X-240639)
- Ceftolozane Impurity 37 (CAS CATO-C4X-240637)
Recommended Standards
- Dopamine Impurity 112 (CAS CATO-C4X-1908112)
- Tetrabenazine Impurity 21 (CAS 4747-99-3)
- Naloxone Impurity 20 (CAS CATO-C4X-149320)
- Coclaurine Impurity 15 (CAS CATO-C4X-27515)
- Lysine Impurity 16 TFA Salt (CAS 13184-13-9(free base))
- Dabigatran impurity 134 (CAS 1912458-32-2)
- Dexmedetomidine Impurity 46 (CAS CATO-C4X-123046)
- 2-Cyclopropylisonicotinaldehyde (CAS 1211528-27-6)
- 1,4-Dihydropyrazine (CAS 3026-16-2)
- 2-(4-Iodophenyl)-1-morpholinoethan-1-one (CAS 364793-89-5)
- (2E)-3-(dimethylamino)-2-(1h-indol-3-ylcarbonyl)-2-propenenitrile (CAS 882562-47-2)
- AM694 3-Iodo Isomer (CAS 1427325-91-4)
- Ethyl 2-(4-methylphenyl)cyclopropane-1-carboxylate (CAS 97023-67-1)
- ((Cys31,Nva34)-Neuropeptide Y (27-36))2 (CAS 172997-92-1)
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