Olaparib Impurity 3 CAS 1956383-44-0
| CAS No. | 1956383-44-0 |
| Molecular Formula | C16H13FN4O2 |
| Molecular Weight | 312.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olaparib Impurity 3.
As a process- or degradation-related impurity, Olaparib Impurity 3 (CAS 1956383-44-0, C16H13FN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 3 (C16H13FN4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H13FN4O2 |
| Molecular Weight | 312.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Olaparib Standards
- Olaparib Impurity 157 (CAS CATO-C4X-1135157)
- Olaparib Impurity N14 (CAS 1983186-05-5)
- Olaparib Impurity 101 (CAS CATO-C4X-1135101)
- Olaparib Impurity 113 (CAS CATO-C4X-1135113)
- Olaparib impurity 143 (CAS CATO-C4X-1135143)
- Olaparib Impurity N2 (CAS 1956324-57-4)
- Olaparib Impurity 117 (CAS CATO-C4X-1135117)
- Olaparib Impurity 95 (CAS CATO-C4X-113595)
Recommended Standards
- Furosemide Impurity 14 (CAS 133989-65-8)
- R 112 (CAS 575474-82-7)
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- Lactose Heptasulfate (CAS CATO-C3D-262596)
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