Olaparib Impurity 95 CAS CATO-C4X-113595
| CAS No. | CATO-C4X-113595 |
| Molecular Formula | C16H10ClFN2O2 |
| Molecular Weight | 316.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Olaparib Impurity 95 (C16H10ClFN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 316.71 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Olaparib Impurity 95 (CAS CATO-C4X-113595, C16H10ClFN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Olaparib Impurity 95 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H10ClFN2O2 |
| Molecular Weight | 316.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Olaparib Standards
- Olaparib Impurity 117 (CAS CATO-C4X-1135117)
- Olaparib impurity 140 (CAS CATO-C4X-1135140)
- Olaparib Impurity 54 (CAS 63964-50-1)
- Olaparib Impurity 62 (CAS CATO-C4X-113562)
- Olaparib Impurity 87 (CAS 1423030-14-1)
- Olaparib Impurity 157 (CAS CATO-C4X-1135157)
- Olaparib Impurity 3 (CAS 1956383-44-0)
- Olaparib Impurity N14 (CAS 1983186-05-5)
Recommended Standards
- DPC 083 (CAS 214287-99-7)
- Voriconazole Impurity 59 (CAS 1185186-22-4)
- 6-Chloro-4-(3-methylbut-1-yn-1-yl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one (CAS 214287-63-5)
- 3-[(E)-2-[(2-Chloro-6-fluorophenyl)methylidene]hydrazin-1-yl]-1,2-dihydroquinoxalin-2-one (CAS 338419-90-2)
- Fluorescein Impurity 6 (CAS 2321-08-6)
- Desacetyl Rifamycin SV (CAS 17750-90-2)
- Azilsartan Impurity 16 (CAS 632322-61-3)
- ((2,3,5,6-Tetramethyl-1,4-phenylene)bis(ethyne-2,1-diyl))dibenzene (CAS 140477-37-8)
- 6-(2-methyl-1H-imidazol-1-yl)pyridine-3-carbonitrile (CAS 1016839-05-6)
- (6-(9,9-Dihexyl-9H-fluoren-2-yl)pyridin-3-yl)methanol (CAS 921754-95-2)
- 2-{[2-(1H-Indol-3-yl)ethyl]amino}-5-nitrobenzonitrile (CAS 852413-37-7)
- 2-Bromo-5-chloropyridine-4-carboxaldehyde (CAS 921630-14-0)
- 3-Bromo-4-ethylpyridine (CAS 38749-76-7)
- D-[Ser]8-Semaglutide (CAS CATO-C4X-2226207)
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