3-(Diphenylmethoxy)-1,2-propanediol CAS 19574-66-4
| CAS No. | 19574-66-4 |
| Molecular Formula | C16H18O3 |
| Molecular Weight | 258.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 3-(Diphenylmethoxy)-1,2-propanediol (C16H18O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-(Diphenylmethoxy)-1,2-propanediol (CAS 19574-66-4) is a certified pharmaceutical impurity reference standard with the molecular formula C16H18O3 and a molecular weight of 258.31 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), 3-(Diphenylmethoxy)-1,2-propanediol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18O3 |
| Molecular Weight | 258.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
Related Diphenylmethoxy Standards
- 2-[(diphenylmethoxy)methyl]oxirane (CAS 6669-15-4)
- 2-(Diphenylmethoxy)-N-ethylamine (CAS 17349-94-9)
- 1-[2-(diphenylmethoxy)ethyl]piperazine (CAS 60703-69-7)
- 5-(Diphenylmethoxy)-1-hydroxy-2-(hydroxymethyl)-1,4-dihydropyridin-4-one (CAS 114875-62-6)
- 2-[2-(diphenylmethoxy)acetamido]-2-phenylacetamide (CAS 1280779-10-3)
- 2-({[4-(Diphenylmethoxy)phenyl]methyl}sulfanyl)-2-phenylacetic acid (CAS 1253528-22-1)
- 4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-[4-[(2-hydroxy-1,1-dimethyl)ethyl]phenyl]butyne (CAS 1159977-34-0)
- 4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-[4-[(2-hydroxy-1,1-dimethyl)ethyl]phenyl]butyne (CAS 1189696-09-0)
Recommended Standards
- 1-(Tert-butyl) 2-methyl (2S,4R)-4-(aminomethyl)pyrrolidine-1,2-dicarboxylate (CAS 194163-92-3)
- (1,2-Dihydroacenaphthylen-5-yl)(phenyl)methanone (CAS 4657-89-0)
- (3R,5S)-1-tert-Butyl 3-methyl 5-aminopiperidine-1,3-dicarboxylate (CAS 191544-79-3)
- (2R)-2-amino-2-(1-(tert-butoxycarbonyl)piperidin-3-yl)acetic acid (CAS 2351455-95-1)
- Avibactam Impurity 32 (CAS 2306254-34-0)
- Baloxavir Impurity 120 (CAS CATO-C4X-2108120)
- Epinephrine /Adrenaline Impurity 136 (CAS CATO-C4X-1849136)
- N-benzyl-1-(3-methylpyridin-2-yl)methanamine (CAS 915919-95-8)
- Methyl 3-((5-chloro-6-oxo-1,6-dihydropyridazin-4-yl)oxy)propanoate (CAS 1346697-67-3)
- 1-(2-fluoroethyl)piperazine hydrochloride (CAS 184042-60-2)
- 3-[4-[3-(2-hydroxyethoxy)propyl]-1-oxo-isoindolin-2-yl]piperidine-2,6-dione (CAS 2599845-88-0)
- 3-Chloro-[1,1'-biphenyl]-4-carboxylic acid (CAS 5728-40-5)
- 2-Cyclopropylethanamine Hydrochloride (CAS 89381-08-8)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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