Iohexol EP Impurity I CAS 196309-19-0
| CAS No. | 196309-19-0 |
| Molecular Formula | C17H23I2N3O8 |
| Molecular Weight | 651.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Iohexol EP Impurity I (CAS 196309-19-0, C17H23I2N3O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Iohexol EP Impurity I (C17H23I2N3O8) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H23I2N3O8 |
| Molecular Weight | 651.19 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Iohexol Standards
- Iohexol EP Impurity M (CAS CATO-C4X-166421)
- Iohexol Impurity G (2,4-diiodo Isomer) (CAS CATO-C4X-166422)
- Iohexol Impurity 32 (CAS CATO-C4X-166432)
- Iohexol Impurity 33 (CAS CATO-C4X-166433)
- Iohexol Impurity 51 (CAS 1651211-78-7)
- Iohexol EP Impurity H (CAS CATO-CP120264)
- Iohexol Impurity 52 (CAS CATO-C4X-166452)
- Iohexol Impurity 31 (CAS 1096689-22-3)
Recommended Standards
- Iopamidol EP Impurity K (CAS 1788899-70-6)
- Iomeprol Impurity 6 (CAS CATO-C4X-18206)
- Isavuconazole Impurity 46 (CAS CATO-C4X-123646)
- Iomeprol Impurity 7 (CAS CATO-C4X-18207)
- Pemetrexed Impurity 7 (CAS 137281-39-1)
- Metoclopramide Impurity 90 (CAS CATO-C4X-141590)
- Methylprednisolone Acetate EP Impurity K (CAS 115321-98-7)
- 2-Hydroxy-3-(methoxycarbonyl)benzoic acid (CAS 101670-85-3)
- 3-Cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (CAS 1006496-16-7)
- 2,4-Dichloro-5-methylbenzodifluoride (CAS 1806346-64-4)
- ({1-[2-(3-Fluorophenyl)ethyl]piperidin-4-yl}-methyl)methylamine (CAS 883542-92-5)
- tert-Butyl 5-iodo-2-azaspiro[3.3]heptane-2-carboxylate (CAS 2852761-36-3)
- N-(4-(Benzyloxy)phenyl)-2-((4-ethyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 579444-09-0)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
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