Ramelteon Imputiry 16 CAS 196597-76-9
| CAS No. | 196597-76-9 |
| Molecular Formula | C11H10Br2O3 |
| Molecular Weight | 350.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 350.00 g/mol gives Ramelteon Imputiry 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ramelteon Imputiry 16 (CAS 196597-76-9, C11H10Br2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C11H10Br2O3, Ramelteon Imputiry 16 contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 350.00 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H10Br2O3 |
| Molecular Weight | 350.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | Br-containing |
Related Ramelteon Standards
- Ramelteon RC 7 (CAS 196597-85-0)
- Ramelteon Impurity K (CAS 196597-77-0)
- Ramelteon Impurity 32 (CAS CATO-C4X-262232)
- Ramelteon Impurity 60 (CAS CATO-C4X-262260)
- Ramelteon RC 9 (CAS 196597-84-9)
- Ramelteon Dimer Impurity (CAS 1365920-38-2)
- Ramelteon Impurity 39 (CAS CATO-C4X-262239)
- Ramelteon Impurity 19 (CAS CATO-C4X-262219)
Recommended Standards
- Ethyl 7-bromo-2,4-dichloro-1,5-naphthyridine-3-carboxylate (CAS 2758819-88-2)
- N,N’-(4,6-Dibromo-1,3-phenylene)diacetamide (CAS 132530-67-7)
- Ethyl 2-bromo-3-(4-bromophenyl)-3-oxopropanoate (CAS 87943-97-3)
- (2,5-Dibromopyridin-3-yl)(morpholino)methanone (CAS 1394291-58-7)
- Adenosine Impurity 3 (CAS CATO-C4X-24193)
- Arotinolol Impurity 77 (CAS CATO-C4X-185477)
- Acetylcysteine Impurity 40 (CAS 25779-79-7)
- 1-(Allyloxy)-2-methylpropan-2-ol (CAS 819-61-4)
- Tert-butyl (3aS,7aR)-octahydro-5H-pyrrolo[3,4-c]pyridine-5-carboxylate (CAS 351362-72-6)
- 4,5-Dimethylisoxazol-3-amine (CAS 13999-39-8)
- 3-Iodo-2-methyl-2H-indazol-6-amine (CAS 2092404-66-3)
- 1-Ethynyl-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (CAS 18083-99-3)
- 1-(((R)-3-Methylpent-1-yn-3-yl)oxy)-3-(piperidin-1-yl)propan-2-ol hydrochloride (CAS 1185064-03-2)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
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