Ramelteon Impurity K CAS 196597-77-0
| CAS No. | 196597-77-0 |
| Molecular Formula | C11H8Br2O2 |
| Molecular Weight | 331.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Ramelteon Impurity K (C11H8Br2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 331.99 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a process- or degradation-related impurity, Ramelteon Impurity K (CAS 196597-77-0, C11H8Br2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ramelteon Impurity K meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8Br2O2 |
| Molecular Weight | 331.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Halogen Content | Br-containing |
Related Ramelteon Standards
- Ramelteon Impurity 32 (CAS CATO-C4X-262232)
- Ramelteon Impurity 60 (CAS CATO-C4X-262260)
- Ramelteon Imputiry 16 (CAS 196597-76-9)
- Ramelteon RC 9 (CAS 196597-84-9)
- Ramelteon RC 7 (CAS 196597-85-0)
- Ramelteon impurity 45 (CAS CATO-C4X-262245)
- Ramelteon Impurity 53 (CAS CATO-C4X-262253)
- Ramelteon Impurity 40 (CAS 1346598-94-4)
Recommended Standards
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- Progesterone Impurity 36 (CAS 88128-61-4)
- Azelastine Impurity 10 (CAS 6315-60-2)
- Dotinurad Impurity 18 (CAS CATO-C4X-249418)
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- Ald-C2-PEG4-azide (CAS 2030118-14-8)
- Dibutyldecylphosphonate (CAS 36378-71-9)
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