Topiroxostat Impurity 59 CAS 19717-43-2
| CAS No. | 19717-43-2 |
| Molecular Formula | C12H10Br2N2 |
| Molecular Weight | 342.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Topiroxostat Impurity 59 (CAS 19717-43-2, C12H10Br2N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Topiroxostat Impurity 59 (C12H10Br2N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 342.03 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Topiroxostat Impurity 59 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10Br2N2 |
| Molecular Weight | 342.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Topiroxostat Standards
- Topiroxostat Impurity 62 (CAS CATO-C4X-105562)
- Topiroxostat Impurity 68 (CAS CATO-C4X-105568)
- Topiroxostat Impurity 26 (CAS CATO-C4X-105526)
- Topiroxostat Impurity 30 (CAS CATO-C4X-105530)
- Topiroxostat Impurity 56 (CAS CATO-C4X-105556)
- Topiroxostat Impurity 14 (CAS CATO-C4X-105514)
- Topiroxostat Impurity 35 (CAS 2044706-78-5)
- Topiroxostat Impurity 16 (CAS CATO-C4X-105516)
Recommended Standards
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- 3-(2-Iodo-4-(trifluoromethyl)phenyl)acrylic acid (CAS 1262012-70-3)
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- 3,4-Dichloropyridine (CAS 55934-00-4)
- Methyl (S)-Fmoc-2-amino-4-iodobutanoate (CAS 1354921-71-3)
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