Deferasirox EP Impurity A CAS 1972-71-0
| CAS No. | 1972-71-0 |
| Molecular Formula | C14H11NO4 |
| Molecular Weight | 257.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Deferasirox EP Impurity A (C14H11NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Deferasirox EP Impurity A (CAS 1972-71-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H11NO4 and a molecular weight of 257.24 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H11NO4 |
| Molecular Weight | 257.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Deferasirox Standards
- Deferasirox Impurity 15 (CAS CATO-C4X-143815)
- Deferasirox Impurity 17 (CAS 155528-92-0)
- Deferasirox Impurity 11 (CAS 586-91-4)
- Deferasirox Impurity 21 (CAS CATO-C4X-143821)
- Deferasirox EP Impurity B (CAS 1218-69-5)
- Deferasirox Impurity 22 (CAS CATO-C4X-143822)
- Deferasirox Impurity 25 (CAS CATO-C4X-143825)
- Deferasirox Impurity 12 (CAS 14685-90-6)
Recommended Standards
- Bumetanide Impurity 69 (CAS CATO-C4X-198669)
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- Alogliptin Impurity 38 (CAS 1246610-72-9)
- Melphalan EP Impurity J (CAS 2724549-95-3)
- Posaconazole Impurity 76 (CAS CATO-C4X-120876)
- Dapoxetine Impurity 107 (CAS CATO-C4X-1439107)
- Avanafil Impurity 20 (CAS 2250242-42-1)
- Decitabine Impurity 13 (CAS 96761-00-1)
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