Bedaquiline (1S,2S) Isomer Impurity 3 CAS 1972612-60-4
| CAS No. | 1972612-60-4 |
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Bedaquiline (1S,2S) Isomer Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 555.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Bedaquiline (1S,2S) Isomer Impurity 3 (CAS 1972612-60-4, C32H31BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Bedaquiline (1S,2S) Isomer Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bedaquiline Standards
- Bedaquiline (Mixture of Diastereomers) (CAS 654655-80-8)
- Bedaquiline (1S,2R) Isomer Impurity 1 (CAS 857086-93-2)
- Bedaquiline Impurity 10 (CAS 916801-19-9)
- Bedaquiline (1R,2R)Isomer Impurity 2 (CAS 857086-94-3)
- Bedaquiline Impurity 20 (CAS CATO-C4X-116720)
- Bedaquiline Impurity 21 (CAS 1228594-68-0)
- (Rac)-Bedaquiline-d6 (CAS 2517573-53-2)
- Bedaquiline-d6 (Mixture of Diastereomers) (CAS CATO-CCAD303718)
Recommended Standards
- (alphaS,betaR)-Bedaquiline (CAS 843663-66-1)
- Tegoprazan Impurity 77 (CAS CATO-C4X-229777)
- 2,3,5-tribenzÂoylÂcytidine (CAS 31652-74-1)
- 4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone (CAS 23220-74-8)
- Ranitidine Impurity 28 (CAS CATO-C4X-137028)
- Benidipine Impurity N10 (CAS 166808-97-5)
- Rimegepant Impurity 73 (CAS 1289024-11-8)
- N,N-dimethyl-4-((phenylamino)methyl)aniline (CAS 3526-44-1)
- (4-(Tert-butyl)phenyl)(2-thioxothiazolidin-3-yl)methanone (CAS 1092332-34-7)
- 2-(5-Amino-1h-1,2,4-triazol-1-yl)acetic acid (CAS 1341722-85-7)
- Trans-4-(piperidin-1-ylmethyl)cyclohexan-1-amine (CAS 1160372-62-2)
- 2-Amino-2-(4-bromo-2-fluorophenyl)acetic Acid Hydrochloride (CAS 1136881-78-1)
- 3-[(2,6-difluorophenyl)carbamoyl]propanoic acid (CAS 1153935-43-3)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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