Bedaquiline (1R,2R)Isomer Impurity 2 CAS 857086-94-3
| CAS No. | 857086-94-3 |
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bedaquiline (1R,2R)Isomer Impurity 2 (CAS 857086-94-3, C32H31BrN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Bedaquiline (1R,2R)Isomer Impurity 2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 555.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Bedaquiline (1R,2R)Isomer Impurity 2 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bedaquiline Standards
- Bedaquiline (Mixture of Diastereomers) (CAS 654655-80-8)
- Bedaquiline (1S,2R) Isomer Impurity 1 (CAS 857086-93-2)
- Bedaquiline Impurity 10 (CAS 916801-19-9)
- Bedaquiline Impurity 20 (CAS CATO-C4X-116720)
- Bedaquiline (1S,2S) Isomer Impurity 3 (CAS 1972612-60-4)
- Bedaquiline Impurity 21 (CAS 1228594-68-0)
- (Rac)-Bedaquiline-d6 (CAS 2517573-53-2)
- Bedaquiline-d6 (Mixture of Diastereomers) (CAS CATO-CCAD303718)
Recommended Standards
- (alphaS,betaR)-Bedaquiline (CAS 843663-66-1)
- Beclometasone Dipropionate Monohydrate EP Impurity E (CAS 887130-68-9)
- Tegoprazan Impurity 77 (CAS CATO-C4X-229777)
- 7720-83-4 Titanium(IV) iodide, anhydrous MFCD00043077 Titanium iodide (TiI4), (T-4)- Titanium iodide (TiI4), ( beta-4)- (CAS 7720-83-4)
- Gefitinib Impurity 50 (CAS 199327-59-8)
- Avanafil Impurity 61 (CAS CATO-C4X-111861)
- Esmolol Impurity 68 (CAS CATO-C4X-189168)
- Allopurinol impurity 18 (CAS CATO-C4X-145818)
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- Perfluoro-2-methyl-3-ethylpentane (CAS 354-97-2)
- 2,3-Dihydro-1h-pyrrolo[3,4-b]quinoline (CAS 34086-64-1)
- (Z)-Hex-3-en-1-yl octanoate (CAS 61444-41-5)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com