Pyrazinamide EP Impurity B CAS 19847-12-2

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.19847-12-2
Molecular FormulaC5H3N3
Molecular Weight105.10 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Pyrazinamide EP Impurity B CAS 19847-12-2 chemical structure

Description

Pyrazinamide EP Impurity B (CAS 19847-12-2) is a certified pharmaceutical impurity reference standard with the molecular formula C5H3N3 and a molecular weight of 105.10 g/mol.

Pyrazinamide EP Impurity B (C5H3N3) contains a nitrile group. Its physicochemical properties are representative of its class; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC5H3N3
Molecular Weight105.10 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1962
Nitrogen Atoms3

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