Nicotinamide EP Impurity E CAS 1986-81-8
| CAS No. | 1986-81-8 |
| Molecular Formula | C6H6N2O2 |
| Molecular Weight | 138.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nicotinamide EP Impurity E.
As a process- or degradation-related impurity, Nicotinamide EP Impurity E (CAS 1986-81-8, C6H6N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nicotinamide EP Impurity E (C6H6N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicotinamide EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6N2O2 |
| Molecular Weight | 138.12 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Nicotinamide Standards
- Nicotinamide 1-Methyl 1,4-Dihydro Impurity (CAS 17750-23-1)
- Nicotinamide impurity 19 (CAS CATO-C4X-200019)
- Nicotinamide Impurity 6 (CAS 6960-22-1)
- Nicotinamide Impurity 7 (CAS 114-33-0)
- Nicotinamide-d4 N-Oxide_x0000_ (d4 Major) (CAS 1246817-64-0)
- Nicotinamide-amide-<SUP>15</SUP>N (CAS 113950-01-9)
- Nicotinamide, 1,4,5,6-tetrahydro- (CAS 7032-11-3)
- Nicotinamide-2,4,5,6-d4 (CAS 347841-88-7)
Recommended Standards
- Acipimox Impurity 7 (CAS 6164-79-0)
- Pirfenidone Impurity 25 (CAS 2512237-43-1)
- Acipimox Impurity 1 (CAS 5521-55-1)
- Pirfenidone Impurity 40 (CAS CATO-C4X-222940)
- Vonoprazan Fumarate Impurity 79 (CAS CATO-C4X-102079)
- Ramelteon 6-Oxo Impurity (CAS 896736-22-4)
- Pregabalin Impurity 111 (CAS CATO-C4X-1312111)
- 1-(2-Aminophenyl)azetidin-3-ol (CAS 1029432-72-1)
- 4-[2-(4-Piperidinylmethoxy)ethyl]morpholine (CAS 946680-57-5)
- ARL 67156 Trisodium Salt (CAS 1021868-83-6)
- 1-(2-Methoxyphenyl)pentan-1-one (CAS 20359-54-0)
- N-oxide Lomeprol Impurity 8 (CAS CATO-C4X-18208)
- (2-Bromo-6-chlorophenyl)boronic acid (CAS 1107580-65-3)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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