Nicotinamide Impurity 6 CAS 6960-22-1

Description

The occurrence of Nicotinamide Impurity 6 is closely related to an amide group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Nicotinamide Impurity 6 (CAS 6960-22-1) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8N2O and a molecular weight of 136.15 g/mol.

Owing to an amide group, a hydroxyl group, an ether linkage, an aromatic ring system, Nicotinamide Impurity 6 is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 136.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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