(3R,4R)-1-(tert-Butoxycarbonyl)-4-(difluoromethyl)pyrrolidine-3-carboxylic acid CAS 1993278-98-0
| CAS No. | 1993278-98-0 |
| Molecular Formula | C11H17F2NO4 |
| Molecular Weight | 265.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(3R,4R)-1-(tert-Butoxycarbonyl)-4-(difluoromethyl)pyrrolidine-3-carboxylic acid (CAS 1993278-98-0) is a high-purity analytical reference standard with the molecular formula C11H17F2NO4 and a molecular weight of 265.25 g/mol.
The molecular framework of (3R,4R)-1-(tert-Butoxycarbonyl)-4-(difluoromethyl)pyrrolidine-3-carboxylic acid (C11H17F2NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), (3R,4R)-1-(tert-Butoxycarbonyl)-4-(difluoromethyl)pyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H17F2NO4 |
| Molecular Weight | 265.25 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (3r)-1-[(tert-butoxy)carbonyl]-5,5-difluoropiperidine-3-carboxylicacid (CAS 2166031-07-6)
- (3S)-1-[(tert-butoxy)carbonyl]-5,5-difluoropiperidine-3-carboxylicacid (CAS 2166022-52-0)
- (2S,4S)-1-(tert-butoxycarbonyl)-4-(difluoromethyl)pyrrolidine-2-carboxylic acid (CAS 474417-79-3)
- (4r)-1-Tert-butoxycarbonyl-3,3-difluoro-piperidine-4-carboxylicacid (CAS 2382269-75-0)
- (R)-1-(6-Methoxypyrimidin-4-yl)pyrrolidin-3-ol (CAS 1354006-76-0)
- Methyl 4-hydroxy-4-methylpent-2-ynoate (CAS 25294-59-1)
- 2-((3-Methoxybenzyl)thio)-3-(4-methoxyphenyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 477331-25-2)
- 2-ethylpiperidine hydrochloride (CAS 1484-99-7)
- 6-Iodoquinolin-2-amine (CAS 880144-59-2)
- 4-(4-(Methylsulfonyl)phenoxy)piperidine hydrochloride (CAS 333987-88-5)
- 3-((4-Methylthiazol-2-yl)amino)butanoic acid (CAS 1094695-16-5)
- 5-Bromo-2-(2-methoxyethoxy)aniline hydrochloride (CAS 1185300-88-2)
- N-Cyclopropyl-3,5-difluoroaniline (CAS 1506097-42-2)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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