1-(4,5-Difluoro-2-hydroxyphenyl)ethan-1-one CAS 199586-38-4
| CAS No. | 199586-38-4 |
| Molecular Formula | C8H6F2O2 |
| Molecular Weight | 172.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(4,5-Difluoro-2-hydroxyphenyl)ethan-1-one (CAS 199586-38-4), molecular formula C8H6F2O2 and molecular weight 172.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4,5-Difluoro-2-hydroxyphenyl)ethan-1-one (C8H6F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 1-(4,5-Difluoro-2-hydroxyphenyl)ethan-1-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O2 |
| Molecular Weight | 172.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | F-containing |
Related Difluoro Standards
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- 2,5-Difluoro-3-methylbenzoic acid (CAS 1003710-01-7)
- 3,5-Difluoro-2-methylbenzoic acid (CAS 1003710-06-2)
- 3,4-Difluoro-5-methylbenzoic acid (CAS 1017778-60-7)
- 3,4-Difluoro-2-methoxybenzaldehyde (CAS 1023023-24-6)
- 3,5-Difluoro-4-methylbenzoic acid (CAS 103877-76-5)
- 2,5-Difluoro-4-methylbenzoic Acid (CAS 103877-80-1)
- 2,2-Difluoro-2-(pyridin-2-yl)acetamide (CAS 1064652-41-0)
Recommended Standards
- 1-(3,4-Difluorophenyl)urea (CAS 263554-12-7)
- 1,3-Dinitrobenzene-d4 (CAS 54247-05-1)
- 1-(3,4-Difluoro-2-hydroxyphenyl)ethan-1-one (CAS 816450-98-3)
- 2-(Difluoromethoxy)benzaldehyde (CAS 71653-64-0)
- 1-(2,3-Dimethylphenyl)-3-(3-fluorophenyl)propan-1-one (CAS 898789-20-3)
- 4-chloro-3-(1H-1,2,3,4-tetrazol-5-yl)benzene-1-sulfonyl chloride (CAS 57320-76-0)
- 4-(Difluoromethyl)-2-fluoro-6-(trifluoromethyl)pyridine (CAS 1806044-67-6)
- 5-(hydroxymethyl)-5-(propan-2-yl)piperidin-2-one (CAS 1909337-78-5)
- 7-Hydroxy-4-methoxy-6-azaindole (CAS 917918-80-0)
- 6-Fluoropyridine-3-sulfonyl fluoride (CAS 1259065-58-1)
- 1-[4-(aminomethyl)phenyl]imidazolidin-2-one (CAS 1038283-11-2)
- 2-Bromo-N,4-dimethyl-6-nitroaniline (CAS 1805598-11-1)
- 2-N-Acetyl-1’,2’-di-O-acetyl-6-biopterin (CAS 81827-31-8)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com