(R)-3-(4-Chlorophenyl)-2-methylpropanoic acid CAS 199679-74-8
| CAS No. | 199679-74-8 |
| Molecular Formula | C10H11ClO2 |
| Molecular Weight | 198.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of (R)-3-(4-Chlorophenyl)-2-methylpropanoic acid (C10H11ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
(R)-3-(4-Chlorophenyl)-2-methylpropanoic acid (CAS 199679-74-8) is a high-purity analytical reference standard with the molecular formula C10H11ClO2 and a molecular weight of 198.65 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (R)-3-(4-Chlorophenyl)-2-methylpropanoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11ClO2 |
| Molecular Weight | 198.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | Cl-containing |
Related R Standards
- 3-(4-Chlorophenyl)-2-methylpropanoic acid (CAS 1012-17-5)
- Methyl 2-(3-chlorophenyl)propanoate (CAS 103040-42-2)
- Methyl 3-(3-chlorophenyl)propanoate (CAS 103040-43-3)
- 3-(4-CHlorophenyl)propanehydrazide (CAS 1132-73-6)
- Methyl 2-(2-chlorophenyl)propanoate (CAS 115615-35-5)
- (E)-3-(4-chlorophenyl)-N'-hydroxypropanimidamide (CAS 1219625-88-3)
- 3-(3-Chlorophenyl)butanoic acid (CAS 1226163-60-5)
- Ethyl 2-(4-Chlorophenyl)acetate (CAS 14062-24-9)
Recommended Standards
- (6-Chlorochroman-3-yl)methanol (CAS 357396-09-9)
- (S)-2-amino-N-(4-chlorophenyl)propanamide (CAS 58112-18-8)
- (3,5-Dimethylphenoxy)acetyl chloride (CAS 78357-63-8)
- 1-(((6-Chloropyridin-3-yl)oxy)methyl)cyclopropanamine (CAS 959957-87-0)
- 2-Phenyl-1h-benzo[d]imidazole-6-sulfonic acid hydrate (CAS 207853-65-4)
- N-(4-aminobenzyl)-2-nitroaniline (CAS 1221792-11-5)
- Benzo[d][1,2,3]triazin-4-amine (CAS 89795-80-2)
- Pyridostigmine (CAS 155-97-5)
- N-[(N'-Hydroxycarbamimidoyl)methyl]benzamide (CAS 949873-85-2)
- (R)-2-Ethylpiperazine Dihydrochloride (CAS 438050-07-8)
- Tulobuterol Impurity 19 (CAS 18366-40-0)
- Tert-butyl ((1-fluoro-3-oxocyclobutyl)methyl)carbamate (CAS 2231675-68-4)
- 6-Nitro-2-(4-nitrophenyl)imidazo[1,2-a]pyridine (CAS 118000-57-0)
- Hexapeptide-9 (CAS 1228371-11-6)
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