Clonazepam EP Impurity A CAS 2011-66-7
| CAS No. | 2011-66-7 |
| Molecular Formula | C13H9ClN2O3 |
| Molecular Weight | 276.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clonazepam EP Impurity A.
Clonazepam EP Impurity A (CAS 2011-66-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H9ClN2O3 and a molecular weight of 276.68 g/mol.
Clonazepam EP Impurity A (C13H9ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H9ClN2O3 |
| Molecular Weight | 276.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Clonazepam Standards
- Clonazepam Impurity 21 (CAS 4306-32-5)
- Clonazepam impurity 18 (CAS 23751-99-7)
- Clonazepam impurity 16 (CAS CATO-C4X-140316)
- Clonazepam Impurity 22 (CAS 16346-60-4)
- Clonazepam impurity 12 (CAS 2246723-47-5)
- Clonazepam impurity 13 (CAS 106351-41-1)
- Clonazepam impurity 17 (CAS 2246723-40-8)
- Clonazepam impurity 15 (CAS CATO-C4X-140315)
Recommended Standards
- N-(4-chlorophenyl)-4-nitrobenzamide (CAS 2585-30-0)
- Chlorpromazine Impurity 20 (CAS CATO-C4X-142120)
- N-(4-Chlorophenyl)-3-nitrobenzamide (CAS 99514-24-6)
- Urapidil Impurity 16 (CAS CATO-C4X-192416)
- Imidacloprid Impurity 1 (CAS 105828-41-9)
- Sulindac Impurity 89 (CAS 37794-15-3)
- Revefenacin impurity 94 (CAS CATO-C4X-203194)
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