Lapatinib Impurity 23 CAS 202197-27-1
| CAS No. | 202197-27-1 |
| Molecular Formula | C13H11ClFNO |
| Molecular Weight | 251.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Lapatinib Impurity 23 (CAS 202197-27-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11ClFNO and a molecular weight of 251.68 g/mol.
Based on its molecular formula C13H11ClFNO, Lapatinib Impurity 23 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11ClFNO |
| Molecular Weight | 251.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Lapatinib Standards
- Lapatinib Impurity 1 (CAS 202197-26-0)
- Lapatinib Impurity 5 (CAS 179246-45-8)
- Lapatinib Impurity 45 -d6 (CAS CATO-C4X-119145)
- Lapatinib Impurity 3 (CAS 59404-86-3)
- Lapatinib Impurity 40 (CAS CATO-C4X-119140)
- Lapatinib Impurity 28 (CAS 443882-99-3)
- Lapatinib Impurity 2 (CAS 202197-25-9)
- Lapatinib Impurity 4 (CAS 6373-46-2)
Recommended Standards
- 2-(4-Chloro-3-methylphenoxy)-5-fluorophenylamine 4107AF 946729-49-3 C13H11ClFNO (CAS 946729-49-3)
- 4-(4-Chloro-2-fluorophenyl)-3h,4h,5h,6h,7h-imidazo[4,5-c]pyridine (CAS 1010902-77-8)
- 2-(2-Chloro-5-methylphenoxy)-5-fluorophenylamine 4106AF 946729-37-9 C13H11ClFNO (CAS 946729-37-9)
- 4-(5-Chloro-2-fluorophenyl)-3h,4h,5h,6h,7h-imidazo[4,5-c]pyridine (CAS 1010913-03-7)
- Ulipristal Impurity 4 (CAS 244206-52-8)
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- 2-((4-Bromo-N-methylphenyl)sulfonamido)acetamide (CAS 904517-36-8)
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