Lapatinib Impurity 1 CAS 202197-26-0
| CAS No. | 202197-26-0 |
| Molecular Formula | C13H11ClFNO |
| Molecular Weight | 251.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Lapatinib Impurity 1 (CAS 202197-26-0) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11ClFNO and a molecular weight of 251.68 g/mol.
Structurally, Lapatinib Impurity 1 (C13H11ClFNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 251.68 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Lapatinib Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11ClFNO |
| Molecular Weight | 251.68 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Lapatinib Standards
- Lapatinib Impurity 23 (CAS 202197-27-1)
- Lapatinib Impurity 5 (CAS 179246-45-8)
- Lapatinib Impurity 45 -d6 (CAS CATO-C4X-119145)
- Lapatinib Impurity 3 (CAS 59404-86-3)
- Lapatinib Impurity 40 (CAS CATO-C4X-119140)
- Lapatinib Impurity 28 (CAS 443882-99-3)
- Lapatinib Impurity 2 (CAS 202197-25-9)
- Lapatinib Impurity 4 (CAS 6373-46-2)
Recommended Standards
- 2-(4-Chloro-3-methylphenoxy)-5-fluorophenylamine 4107AF 946729-49-3 C13H11ClFNO (CAS 946729-49-3)
- 2-(2-Chloro-5-methylphenoxy)-5-fluorophenylamine 4106AF 946729-37-9 C13H11ClFNO (CAS 946729-37-9)
- N'-(6-chloropyridin-2-yl)-2-(1H-1,2,4-triazol-1-yl)acetimidohydrazide (CAS 477852-43-0)
- 4-(4-Chloro-2-fluorophenyl)-3h,4h,5h,6h,7h-imidazo[4,5-c]pyridine (CAS 1010902-77-8)
- Mometasone Impurity C84 (CAS 722495-06-9)
- Cefpodoxime Proxetil Impurity 41 (CAS 98298-66-9)
- Sunitinib Impurity 28 (CAS CATO-C4X-133328)
- 4-Aminothiomorpholine 1,1-Dioxide (CAS 26494-76-8)
- 3-Amino-N-(2,5-dimethylphenyl)propanamide hydrochloride (CAS 1268990-65-3)
- 2-((5-Amino-4-phenylthiazol-2-yl)thio)-N-(4-fluorobenzyl)acetamide (CAS 1021030-54-5)
- 3-amino-3-(4-chlorophenyl)prop-2-enenitrile (CAS 25354-58-9)
- 3-Phenylbut-2-enoic acid (CAS 1199-20-8)
- 2,6,8-Trimethylquinolin-4(1H)-one (CAS 54598-18-4)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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