Edoxaban impurity 136 CAS 2024614-15-9
| CAS No. | 2024614-15-9 |
| Molecular Formula | C21H30ClN5O5 |
| Molecular Weight | 467.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Edoxaban impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Edoxaban impurity 136 (CAS 2024614-15-9) is a certified pharmaceutical impurity reference standard with the molecular formula C21H30ClN5O5 and a molecular weight of 467.95 g/mol.
The molecular framework of Edoxaban impurity 136 (C21H30ClN5O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H30ClN5O5 |
| Molecular Weight | 467.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Edoxaban Standards
- Edoxaban Impurity 139 (CAS 480451-98-7)
- Edoxaban Impurity 36 (1S,2R,4S) (CAS 480452-36-6)
- Edoxaban Impurity 37 (1R,2S,4R) (CAS CATO-C4X-106337)
- Edoxaban Impurity 91 (CAS 1255529-38-4)
- Edoxaban Impurity 92 (CAS CATO-C4X-106392)
- Edoxaban impurity 130 (CAS CATO-C4X-1063130)
- Edoxaban Impurity 95 (CAS 480450-85-9)
- Edoxaban Impurity 69 (CAS CATO-C4X-106369)
Recommended Standards
- N-(3-(1H-Indol-3-yl)-1-(naphthalen-2-ylamino)-1-oxopropan-2-yl)-2-chlorobenzamide (CAS 956809-39-5)
- 5-(1-((2-Chlorophenyl)sulfonyl)pyrrolidin-2-yl)-3-((phenylsulfonyl)methyl)-1,2,4-oxadiazole (CAS 672925-66-5)
- 4-Chloro-N-[(4-ethyl-5-{[(4-nitrophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)methyl]benzene-1-sulfonamide (CAS 338421-96-8)
- Citarinostat (CAS 1316215-12-9)
- Lidocaine Impurity 101 (CAS CATO-C4X-1679101)
- Nintedanib Impurity 93 (CAS CATO-C4X-181493)
- Dabigatran Impurity 138 (CAS CATO-C4X-1089138)
- 2-bromo-N-(1H-1,2,4-triazol-3-yl)acetamide (CAS 885987-83-7)
- 2-(2-Furyl)alanine (CAS 2644-43-1)
- 2-Amino-n-tert-butylacetamide (CAS 71034-40-7)
- Brd 4354 (CAS 315698-07-8)
- Pregabalin Impurity 2 (CAS 75143-89-4)
- 4-Bromo-2-chloro-5-iodopyridine (CAS 1354021-06-9)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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