Edoxaban Impurity 139 CAS 480451-98-7
| CAS No. | 480451-98-7 |
| Molecular Formula | C21H30ClN5O5 |
| Molecular Weight | 467.95 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Edoxaban Impurity 139 (CAS 480451-98-7) is a certified pharmaceutical impurity reference standard with the molecular formula C21H30ClN5O5 and a molecular weight of 467.95 g/mol.
Structurally, Edoxaban Impurity 139 (C21H30ClN5O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 467.95 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Edoxaban Impurity 139 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H30ClN5O5 |
| Molecular Weight | 467.95 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Edoxaban Standards
- Edoxaban impurity 136 (CAS 2024614-15-9)
- Edoxaban Impurity 36 (1S,2R,4S) (CAS 480452-36-6)
- Edoxaban Impurity 37 (1R,2S,4R) (CAS CATO-C4X-106337)
- Edoxaban Impurity 91 (CAS 1255529-38-4)
- Edoxaban Impurity 92 (CAS CATO-C4X-106392)
- Edoxaban impurity 130 (CAS CATO-C4X-1063130)
- Edoxaban Impurity 95 (CAS 480450-85-9)
- Edoxaban Impurity 69 (CAS CATO-C4X-106369)
Recommended Standards
- N-(3-(1H-Indol-3-yl)-1-(naphthalen-2-ylamino)-1-oxopropan-2-yl)-2-chlorobenzamide (CAS 956809-39-5)
- 5-(1-((2-Chlorophenyl)sulfonyl)pyrrolidin-2-yl)-3-((phenylsulfonyl)methyl)-1,2,4-oxadiazole (CAS 672925-66-5)
- 4-Chloro-N-[(4-ethyl-5-{[(4-nitrophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)methyl]benzene-1-sulfonamide (CAS 338421-96-8)
- Citarinostat (CAS 1316215-12-9)
- Brexpiprazole impurity 107 (CAS 2549192-46-1（free base）)
- Abiraterone Impurity 55 (CAS 1429742-49-3)
- Prochlorperazine Impurity 8 (CAS CATO-C4X-19668)
- Brexpiprazole Impurity 44 (CAS CATO-C4X-113144)
- 6-Chloro-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-amine (CAS 1178583-28-2)
- Methyl 3-hydroxy-2,4-dimethylbenzoate (CAS 1801689-59-7)
- Myosin Light Chain Kinase (480-501) (CAS 313642-00-1)
- (2R,2'R)-1,1'-Bis((6-methylpyridin-2-yl)methyl)-2,2'-bipyrrolidine (CAS 1022094-39-8)
- (3E,5E)-1-Benzyl-3,5-bis[(thiophen-2-yl)methylidene]piperidin-4-one (CAS 1214740-82-5)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
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