Quetiapine Impurity N2 CAS 20290-48-6
| CAS No. | 20290-48-6 |
| Molecular Formula | C13H9NO2S |
| Molecular Weight | 243.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Quetiapine Impurity N2 (CAS 20290-48-6, C13H9NO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Quetiapine Impurity N2 (C13H9NO2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 243.28 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Quetiapine Impurity N2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9NO2S |
| Molecular Weight | 243.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Quetiapine Standards
- Quetiapine impurity 83 (CAS 2101854-40-2)
- Quetiapine Impurity 55 (CAS 54920-98-8)
- Quetiapine Impurity 32 (CAS 13745-86-3)
- Quetiapine Impurity 61 (CAS 65141-02-8)
- Quetiapine Impurity 58 (CAS CATO-C4X-124458)
- Quetiapine Impurity 54 (CAS 4171-83-9)
- Quetiapine Impurity 26 (CAS 13509-33-6)
- Quetiapine Impurity SF (CAS 22871-33-6)
Recommended Standards
- PMX 464 (CAS 485842-97-5)
- S-(Dimethylcarbamoylmethyl) O,O-Dimethyl Ester Phosphorodithioic Acid (CAS 60823-19-0)
- N-Methyl(p-tosyl)carbamic Acid Methyl Ester (CAS 32258-50-7)
- S-Benzyl-L-cysteine Sulfone (CAS 25644-88-6)
- Atrasentan Impurity 5 (CAS CATO-C4X-33475)
- Aripiprazole impurity 20 (CAS 795313-24-5)
- Cefprozil EP Impurity H (CAS CATO-C4X-149214)
- Ethyl 4-hydroxybicyclo[2.2.2]octane-1-carboxylate (CAS 72948-78-8)
- 2,2'-(2-Bromo-5-(difluoromethyl)-1,4-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 2377606-64-7)
- H-Phe-Ile-OH (CAS 22951-94-6)
- 2-Amino-N-(4-(tert-butyl)phenyl)acetamide (CAS 938337-20-3)
- 5-(Methylsulfonyl)furan-2-carboxylic Acid (CAS 23423-91-8)
- 4-((9-(Hydroxymethyl)-9H-purin-6-yl)thio)but-2-yn-1-ol (CAS 52185-93-0)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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