Apixaban Impurity 5 CAS 2029205-64-7
| CAS No. | 2029205-64-7 |
| Molecular Formula | C24H22ClN5O3 |
| Molecular Weight | 463.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apixaban Impurity 5.
CATO supplies Apixaban Impurity 5 (CAS 2029205-64-7), a pharmacopoeial impurity reference standard (molecular formula C24H22ClN5O3, MW 463.92 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Apixaban Impurity 5 (C24H22ClN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 463.92 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H22ClN5O3 |
| Molecular Weight | 463.92 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Apixaban Standards
- Apixaban Impurity 154 (CAS CATO-C4X-1088154)
- Apixaban Impurity 156 (CAS CATO-C4X-1088156)
- Apixaban-13C，d3 (CAS 1261393-15-0)
- Apixaban Impurity 86 (CAS CATO-C4X-108886)
- Apixaban Impurity 68 (CAS CATO-C4X-108868)
- Apixaban Impurity 108 (CAS CATO-C4X-1088108)
- Apixaban-d3 (CAS 1131996-12-7)
- Apixaban Impurity 1 (CAS 503614-92-4)
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