3,4,5-Trifluoroanisole CAS 203245-17-4
| CAS No. | 203245-17-4 |
| Molecular Formula | C7H5F3O |
| Molecular Weight | 162.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3,4,5-Trifluoroanisole is closely related to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3,4,5-Trifluoroanisole (CAS 203245-17-4), molecular formula C7H5F3O and molecular weight 162.11 g/mol, is a CATO reference standard with documented purity and traceability.
3,4,5-Trifluoroanisole (C7H5F3O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5F3O |
| Molecular Weight | 162.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
Related Trifluoroanisole Standards
Recommended Standards
- 2-Amino-6-(trifluoromethyl)pyridine (CAS 34486-24-3)
- 3,4,5-Trifluorobenzyl Alcohol (CAS 220227-37-2)
- 2-Amino-5-(trifluoromethyl)pyridine (CAS 74784-70-6)
- 3,4,6-Trifluoro-1,2-benzenediamine (CAS 363-74-6)
- (E)-3-(Cyclohex-1-en-1-yl)acrylic acid (CAS 56453-88-4)
- 3-(3-Methoxyphenoxy)butan-2-amine (CAS 1250221-15-8)
- 5-((4-Bromophenoxy)methyl)-1,3,4-thiadiazol-2-amine (CAS 299441-95-5)
- Oxacillin Impurity 11 (CAS CATO-C4X-232111)
- 5-Phenylbenzo[d]oxazole (CAS 201415-38-5)
- (3-Methyl-5-(pyridin-2-yl)phenyl)boronic acid (CAS 2225170-54-5)
- 4-Ethyl-5-(piperidin-4-yl)-4h-1,2,4-triazole-3-thiol hydrochloride (CAS 1158560-78-1)
- 2-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1,5,6,7,8,9-hexahydroimidazo[1,2-a]azepin-4-ium bromide (CAS 478945-28-7)
- Ketoconazole Impurity 11 (CAS 84682-23-5)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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