Aripiprazole Impurity N4 CAS 203395-84-0
| CAS No. | 203395-84-0 |
| Molecular Formula | C23H28BrN3O2 |
| Molecular Weight | 458.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Aripiprazole Impurity N4 (C23H28BrN3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Aripiprazole Impurity N4 (CAS 203395-84-0, C23H28BrN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aripiprazole Impurity N4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H28BrN3O2 |
| Molecular Weight | 458.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Aripiprazole Standards
- Aripiprazole Impurity 43 (CAS CATO-C4X-100843)
- Aripiprazole-d8 (CAS 1089115-04-7)
- Aripiprazole-d8 (CAS 1089115-06-9)
- Aripiprazole Impurity 2 (CAS CATO-C4X-10082)
- Aripiprazole Impurity 82 (CAS CATO-C4X-100882)
- Aripiprazole Impurity 4 (CAS 1424858-02-5)
- Aripiprazole Impurity 13 (CAS 573691-11-9)
- Aripiprazole EP Impurity F (CAS 573691-09-5)
Recommended Standards
- 4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide (CAS 1090528-71-4)
- 4,4,5,5-Tetramethyl-2-(4-(1,2,2-triphenylvinyl)phenyl)-1,3,2-dioxaborolane (CAS 1260865-91-5)
- 4-(Bis((4-chlorophenyl)thio)methylene)-2-phenyloxazol-5(4H)-one (CAS 67002-19-1)
- (5-((3,5-Dichlorophenyl)thio)-4-isopropyl-1-(quinolin-3-ylmethyl)-1H-imidazol-2-yl)methanol (CAS 178980-74-0)
- Upadacitinib Impurity 196 (CAS CATO-C4X-2405196)
- Lenvatinib Impurity 38 (CAS CATO-C4X-114038)
- Ribavirin Impurity 25 (CAS 33949-18-7)
- Methyl 2-(3-chloro-5-fluorophenyl)benzoate (CAS 1820640-97-8)
- N-methyl-1-(4-(pyridin-4-yl)phenyl)methanamine (CAS 852180-64-4)
- 1-(4-Aminophenyl)-2-(dimethylamino)propane-1,3-diol (CAS 131392-15-9)
- Trimidox - API Standards (CAS 95933-74-7)
- 6-Fluorochroman-3-one (CAS 944904-05-6)
- (4-BORONOPHENYL)(PYRROLIDIN-1-YL)METHANONE 389621-81-2 4-BORONO-N-(1-PYRROLIDINYL)BENZAMIDE 4-PYRROLIDINYLCARBONYLPHENYLBORONIC ACID BC002043 BORONIC ACID, [4-(1-PYRROLIDINYLCARBONYL)PHENYL]- [4-(1-PYRROLIDINYLCARBONYL)PHENYL]-BORONIC ACID (CAS 389621-81-2)
- Atrial Natriuretic Peptide (ANP)(1-28) Alpha (Human, Ovine, Canine) (CAS 91917-63-4)
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