Aripiprazole EP Impurity D CAS 203395-82-8
| CAS No. | 203395-82-8 |
| Molecular Formula | C23H28ClN3O2 |
| Molecular Weight | 413.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aripiprazole EP Impurity D is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Aripiprazole EP Impurity D (CAS 203395-82-8), a pharmacopoeial impurity reference standard (molecular formula C23H28ClN3O2, MW 413.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Aripiprazole EP Impurity D (C23H28ClN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aripiprazole EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H28ClN3O2 |
| Molecular Weight | 413.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Aripiprazole Standards
- Aripiprazole EP Impurity C (CAS 203395-81-7)
- Aripiprazole Impurity N17 (CAS 1076199-56-8)
- Aripiprazole Impurity 67 (CAS CATO-C4X-100867)
- Aripiprazole Impurity 46 (CAS CATO-C4X-100846)
- Aripiprazole Impurity 85 (CAS CATO-C4X-100885)
- Aripiprazole Impurity 17 (CAS 1424857-89-5)
- Aripiprazole EP Impurity E (CAS 129722-25-4)
- Aripiprazole Impurity 49 (CAS 882880-12-8)
Recommended Standards
- 3-Chloro-N-(4-hydroxy-3,5-bis(pyrrolidin-1-ylmethyl)phenyl)benzamide (CAS 91111-99-8)
- N-(3-(1H-Naphtho[2,3-d]imidazol-2-yl)propyl)-3-chloro-4-methylbenzenesulfonamide (CAS 606133-54-4)
- Rupatadine impurity 47 (CAS CATO-C4X-102747)
- Ethyl 4-([1,1'-biphenyl]-4-yl)-2-(3-chloropropanamido)thiophene-3-carboxylate (CAS 315684-10-7)
- Apalutamide Impurity 52 (CAS 1803821-36-4)
- Vinpocetine Impurity 40 (CAS CATO-C4X-184340)
- Axitinib Impurity 45 (CAS CATO-C4X-107145)
- methyl[(2S)-piperidin-2-ylmethyl]amine dihydrochloride (CAS 2059913-71-0)
- 5-(4-Chlorophenyl)-4H-1,2,4-triazole-3-carbaldehyde (CAS 26899-27-4)
- 2-Methyl-5-propoxybenzaldehyde (CAS 2230481-33-9)
- n-Cyclopropyl-n-(1,5-dimethyl-1h-pyrazole-4-carbonyl)glycine (CAS 1178851-66-5)
- 3-(2-Bromophenyl)-5-(3,4-diethoxyphenyl)-1H-1,2,4-triazole (CAS 1416347-31-3)
- 5-Ethyl-8-methylquinoline (CAS 172042-27-2)
- Peptide 434 (CAS CATO-CPTD788434)
Why CATO?
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