Melatonin impurity 16 CAS 203442-76-6
| CAS No. | 203442-76-6 |
| Molecular Formula | C27H32N4O4 |
| Molecular Weight | 476.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Melatonin impurity 16.
Melatonin impurity 16 (CAS 203442-76-6) is a certified pharmaceutical impurity reference standard with the molecular formula C27H32N4O4 and a molecular weight of 476.57 g/mol.
Structurally, Melatonin impurity 16 (C27H32N4O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 476.57 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Melatonin impurity 16 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H32N4O4 |
| Molecular Weight | 476.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Nitrogen Atoms | 4 |
Related Melatonin Standards
- Melatonin impurity 17 (CAS 203442-77-7)
- Melatonin impurity 10 (CAS CATO-C4X-229210)
- Melatonin Impurity 21 (CAS 176244-65-8)
- Melatonin impurity 12 (CAS CATO-C4X-229212)
- Melatonin Impurity 29 (CAS 1020701-51-2)
- Melatonin 2-Iodo Impurity (CAS 93515-00-5)
- Melatonin Impurity 33 (CAS 14670-08-7)
- Melatonin Impurity 27 (CAS 188397-02-6)
Recommended Standards
- BAY 60-7550, 98% (HPLC) (CAS 439083-90-6)
- 5-Chloro-1-(2,4-dichlorobenzyl)-N-(3,5-dichlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 242797-25-7)
- Ensifentrine impurity 35 (CAS CATO-C4X-335335)
- 4-(N-Butyl-N-methylsulfamoyl)-N-(3-ethyl-6-nitrobenzo[d]thiazol-2(3H)-ylidene)benzamide (CAS 850910-62-2)
- Linaclotide impurity 38 (CAS CATO-C4X-210638)
- Upadacitinib Impurity 151 (CAS CATO-C4X-2405151)
- Celecoxib Impurity 52 (CAS 90090-38-3)
- (S)-tert-Butyl 2-((2-chloro-N-cyclopropylacetamido)methyl)pyrrolidine-1-carboxylate (CAS 1353999-32-2)
- (5R)-5-methylpiperazin-2-one (CAS 1240589-51-8)
- 6-Amino-5-cyclopropylpyrimidin-2(1H)-one (CAS 137937-76-9)
- 2-Bromo-5-methoxypyridine-4-sulfonyl chloride (CAS 1261467-92-8)
- Iopamidol Impurity 28 (CAS 219851-75-9)
- 3-Bromo-5-chloro-2-methylpyrazolo[1,5-a]pyrimidine (CAS 1785626-91-6)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
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