Iopamidol Impurity 28 CAS 219851-75-9
| CAS No. | 219851-75-9 |
| Molecular Formula | C16H4Cl2I6N2O5 |
| Molecular Weight | 1136.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 1136.55 g/mol gives Iopamidol Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Iopamidol Impurity 28 (CAS 219851-75-9) is a certified pharmaceutical impurity reference standard with the molecular formula C16H4Cl2I6N2O5 and a molecular weight of 1136.55 g/mol.
The molecular framework of Iopamidol Impurity 28 (C16H4Cl2I6N2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H4Cl2I6N2O5 |
| Molecular Weight | 1136.55 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Iopamidol Standards
- Iopamidol Impurity 20 (CAS CATO-C4X-145020)
- Iopamidol Impurity 19 (CAS CATO-C4X-145019)
- Iopamidol Impurity 36 (CAS CATO-C4X-145036)
- Iopamidol EP Impurity E (CAS 60166-92-9)
- Iopamidol Impurity 51 (CAS CATO-C4X-145051)
- Iopamidol Impurity 26 (CAS CATO-C4X-145026)
- Iopamidol Impurity 50 (CAS CATO-C4X-145050)
- Iopamidol Impurity 56 (CAS CATO-C4X-145056)
Recommended Standards
- C12-200 (CAS 1220890-25-4)
- 1-(1-mercaptocyclohexaneacetic acid)-2-(O-ethyl-L-tyrosine)-4-L-valine-8-L-arginine-Vasopressin (CAS 77453-01-1)
- 6A-Deoxy-6A-fluoro-β-Cyclodextrin (CAS 99552-37-1)
- Caspofungin impurity 57 (CAS CATO-C4X-157557)
- Lansoprazole Impurity 11 (CAS 1329838-16-5)
- Mometasone Impurity 32 (CAS CATO-C4X-170432)
- Linagliptin Impurity 33 (CAS CATO-C4X-110133)
- 3-(Phenylsulfonyl)pyrazine-2-carbonitrile (CAS 74002-68-9)
- (4-Ethoxybenzyl)triphenylphosphonium chloride (CAS 69743-35-7)
- (4-Aminopiperidin-1-yl)(3-methylfuran-2-yl)methanone (CAS 926184-87-4)
- Ethyl 2-(propylamino)acetate (CAS 40693-96-7)
- Sulpiride Impurity 18 (CAS 326882-45-5)
- tert-Butyl(3-((4-methoxyphenyl)amino)benzyl)carbamate (CAS 886362-41-0)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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