Amitriptyline-d6 Hydrochloride CAS 203645-63-0
| CAS No. | 203645-63-0 |
| Molecular Formula | - |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Amitriptyline-d6 Hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Amitriptyline-d6 Hydrochloride (CAS 203645-63-0) is a high-purity analytical reference standard with the molecular formula C20H17D6NHCl and a molecular weight of 319.90 g/mol.
The molecular framework of Amitriptyline-d6 Hydrochloride (C20H17D6NHCl) is characterized by deuterium isotope labeling, a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C20H17D6N HCl |
| Molecular Weight | 319.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amitriptyline Standards
- Amitriptyline EP Impurity D (CAS 1159-03-1)
- Amitriptyline EP Impurity F (CAS 1159-82-6)
- Amitriptyline EP Impurity A (CAS 1210-35-1)
- Amitriptyline Hydrochloride - Impurity F (Oxalate Salt) (CAS 1246833-15-7)
- Amitriptyline-13C3 Hydrochloride (CAS 1329837-86-6)
- Amitriptyline EP Impurity C-d3 HCl (CAS 203784-52-5)
- Amitriptyline EP Impurity E HCl (Mixture of Diastereomers) (CAS 26360-49-6(free base))
- Amitriptyline EP Impurity E (CAS 26360-49-6（free base）)
Recommended Standards
- 4-Ethyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS 1243382-71-9)
- (3-Chloro-4-fluorophenyl)(4-methoxyphenyl)methanone (CAS 760192-87-8)
- 2,7-Dimethyl-9H-fluorene (CAS 2851-80-1)
- 5-(3-Chlorophenyl)dihydro-2(3H)-furanone (CAS 875256-56-7)
- Methyl n-[(4-aminophenyl)methyl]-N-methylcarbamate (CAS 1156184-09-6)
- 7-((2R,4aR,5R,7aR)-2-((S)-1,1-Difluoro-3-methylpentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic acid (CAS 333963-42-1)
- n-[(2-methylphenyl)methyl]cyclopropanamine (CAS 625435-05-4)
- 2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide (CAS 1928707-56-5)
- 7-Iodo-1H-indazole-3-carboxylic acid (CAS 1260657-38-2)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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