Nintedanib Impurity 10 CAS 2037385-84-3
| CAS No. | 2037385-84-3 |
| Molecular Formula | C13H18N4O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 314.77 g/mol gives Nintedanib Impurity 10 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nintedanib Impurity 10 (CAS 2037385-84-3, C13H18N4O3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H18N4O3HCl, Nintedanib Impurity 10 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 314.77 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Nintedanib Impurity 10 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H18N4O3 HCl |
| Molecular Weight | 314.77 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Nintedanib Standards
- Nintedanib Impurity 158 (CAS 1023942-14-4)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 6 (CAS 1139453-98-7)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Rivaroxaban Impurity 69 (CAS CATO-C4X-109069)
- Vortioxetine Impurity 129 HCl (CAS CATO-C4X-1056129)
- Avibactam Impurity 88 (CAS CATO-C4X-134888)
- 2-Fluoro-5-methoxy-3-(trifluoromethyl)benzonitrile (CAS 1373920-99-0)
- 6-Amino-7-fluoro-3,3-dimethyl-3,4-dihydroquinolin-2(1H)-one (CAS 2672571-35-4)
- (4-Chloro-3-fluorophenyl)(2-fluorobenzyl)sulfane (CAS 1443327-31-8)
- Phenytoin Impurity 2 (CAS 36898-62-1)
- N-Cbz-3(R)-fluoropyrrolidine (CAS 163457-21-4)
- Peramivir Impurity 1 (CAS 1170354-97-8)
- Palmitoyl Tripeptide-5 TFA (CAS 623172-55-4（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com