Nintedanib Impurity N24 CAS 1139455-52-9
| CAS No. | 1139455-52-9 |
| Molecular Formula | C32H35N5O4 |
| Molecular Weight | 553.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nintedanib Impurity N24 (CAS 1139455-52-9) is a certified pharmaceutical impurity reference standard with the molecular formula C32H35N5O4 and a molecular weight of 553.65 g/mol.
The molecular framework of Nintedanib Impurity N24 (C32H35N5O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H35N5O4 |
| Molecular Weight | 553.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 5 |
Related Nintedanib Standards
- Nintedanib Impurity 101 (CAS CATO-C4X-1814101)
- Nintedanib Impurity 87 (CAS CATO-C4X-181487)
- Nintedanib Impurity 96 (CAS CATO-C4X-181496)
- Nintedanib impurity 108 (CAS CATO-C4X-1814108)
- Nintedanib impurity 81 (CAS CATO-C4X-181481)
- Nintedanib impurity 183 (CAS CATO-C4X-1814183)
- Nintedanib Impurity 19 (CAS 3029792-02-4)
- Nintedanib Impurity 21 (CAS CATO-C4X-181421)
Recommended Standards
- Venetoclax Impurity 124 (CAS CATO-C4X-2495124)
- 2,4-Dibromo-6-(3,4,5-tribromo-1H-pyrrol-2-yl)phenol (CAS 10245-81-5)
- Netadil Impurity 1 (CAS 1253955-19-9)
- Z-Leu-Leu-Tyr-α-keto aldehyde (CAS 204649-66-1)
- Enrofloxacin Impurity 5 (CAS CATO-C4X-16285)
- (S)-Levetiracetam EP Impurity A (CAS 102849-49-0)
- Alprazolam Impurity 22 (CAS CATO-C4X-146022)
- (1-(Thiophen-2-ylsulfonyl)piperidin-3-yl)methanamine hydrochloride (CAS 1261235-52-2)
- Ziprasidone EP Impurity B (CAS 1159977-56-6)
- Methyl 1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide (CAS 503310-57-4)
- 3-(2-(Dimethylamino)ethoxy)propan-1-amine (CAS 65573-13-9)
- 5-Nitro-2-(trifluoromethoxy)benzaldehyde (CAS 160503-78-6)
- Benzyl 3,9-diazaspiro[5.6]Dodecane-9-carboxylate (CAS 2387599-42-8)
- Peptide Impurity 28 (CAS 1350456-64-2)
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