Lenvatinib Impurity 170 CAS 20404-02-8
| CAS No. | 20404-02-8 |
| Molecular Formula | C6H2Cl3NO3 |
| Molecular Weight | 242.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lenvatinib Impurity 170 (CAS 20404-02-8, C6H2Cl3NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Lenvatinib Impurity 170 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 242.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H2Cl3NO3 |
| Molecular Weight | 242.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lenvatinib Standards
- Lenvatinib Impurity 54 (CAS 2143930-77-0)
- Lenvatinib Impurity 35 (CAS 771464-30-3)
- Lenvatinib Impurity 136 (CAS CATO-C4X-1140136)
- Lenvatinib Impurity 147 (CAS 863786-02-1)
- Lenvatinib Impurity 153 (CAS CATO-C4X-1140153)
- Lenvatinib Impurity 154 (CAS CATO-C4X-1140154)
- Lenvatinib Impurity 176 (CAS CATO-C4X-1140176)
- Lenvatinib Impurity 20 (CAS 417721-36-9)
Recommended Standards
- 8-HEXADECANOL (CAS 19781-83-0)
- 1-Hexadecanol (CAS 36653-82-4)
- 3,4,5-Trichloro-1,6-dihydro-6-oxo-2-Pyridinecarboxylic Acid 3,4,5-Trichloro-6-hydroxy-2-picolinic Acid 3,4,5-Trichloro-6-hydroxy-2-pyridinecarboxylic Acid 73455-14-8 (CAS 73455-14-8)
- 2-Hexyl-1-Decanol (CAS 2425-77-6)
- Atorvastatin EP Impurity H (CAS 125995-03-1)
- Adrenaline EP Impurity D（TFA salt） (CAS 317351-40-9（free base）)
- Landiolol Impurity 8 HCl (CAS CATO-C4X-26218)
- Methyl 1-(2-ethoxy-2-oxoethyl)-6-(4-methoxyphenyl)-3-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011399-57-7)
- Candesartan Cilexetil Impurity 43 (CAS CATO-C4X-123443)
- 6-Bromo-4-chloro-3-methylquinoline (CAS 188256-40-8)
- Benzyl 3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 142266-67-9)
- Methyl 1-(chlorosulfonyl)cyclohexanecarboxylate (CAS 1312138-63-8)
- 3-(Cyclohexyloxy)aniline (CAS 109421-10-5)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
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