Lenvatinib Impurity 176 CAS CATO-C4X-1140176
| CAS No. | CATO-C4X-1140176 |
| Molecular Formula | C11H9ClN2O2 |
| Molecular Weight | 236.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C11H9ClN2O2, Lenvatinib Impurity 176 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 236.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lenvatinib Impurity 176 (CAS CATO-C4X-1140176, C11H9ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9ClN2O2 |
| Molecular Weight | 236.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lenvatinib Standards
- Lenvatinib Impurity 136 (CAS CATO-C4X-1140136)
- Lenvatinib Impurity 147 (CAS 863786-02-1)
- Lenvatinib Impurity 153 (CAS CATO-C4X-1140153)
- Lenvatinib Impurity 154 (CAS CATO-C4X-1140154)
- Lenvatinib Impurity 20 (CAS 417721-36-9)
- Lenvatinib Impurity 79 (CAS CATO-C4X-114079)
- Lenvatinib Impurity 91 (CAS CATO-C4X-114091)
- Lenvatinib Impurity 35 (CAS 771464-30-3)
Recommended Standards
- Alanyl Glutamine Impurity 1 (CAS 159141-33-0)
- (E)-N-{1-[3-(4-chlorophenyl)-1,2-oxazol-5-yl]ethylidene}hydroxylamine 478066-73-8 7M-512S (CAS 478066-73-8)
- Alanyl Glutamine Impurity 2 (CAS CATO-C4X-19742)
- N-(7-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)acetamide (CAS 62626-72-6)
- Cefuroxime Axetil Impurity 6 (CAS CATO-C4X-14366)
- Dobutamine Impurity 32 (CAS CATO-C4X-129832)
- Vazegepant Impurity 1 (CAS CATO-C4X-32001)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-phenylpent-4-enoic acid (CAS 215190-24-2)
- 7-Nitro-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine (CAS 1260671-19-9)
- 5-Amino-N-benzyloxycarbonylpentanol (CAS 87905-98-4)
- (S)-2-((tert-butoxycarbonyl)amino)-2-methylbut-3-ynoic acid (CAS 391678-36-7)
- (3-Fluoro-4-(2-fluoropyridin-4-yl)phenyl)methanamine hydrochloride (CAS 1449117-60-5)
- Ethyl 2-(3-methyl-1h-pyrazol-1-yl)butanoate (CAS 1173070-61-5)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
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