[4-(difluoromethoxy)phenyl](phenyl)methanamine hydrochloride CAS 2044872-13-9
| CAS No. | 2044872-13-9 |
| Molecular Formula | C14H13F2NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
[4-(difluoromethoxy)phenyl](phenyl)methanamine hydrochloride (CAS 2044872-13-9), molecular formula C14H13F2NOHCl and molecular weight 285.72 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, [4-(difluoromethoxy)phenyl](phenyl)methanamine hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 285.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H13F2NO HCl |
| Molecular Weight | 285.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related difluoromethoxy Standards
- 2-(2-(Difluoromethoxy)phenyl)ethan-1-ol (CAS 1000533-82-3)
- 4-(Difluoromethoxy)-2-iodoaniline (CAS 1000801-26-2)
- 3-(4-(Difluoromethoxy)phenyl)propanoic acid (CAS 1000932-18-2)
- 4-(Difluoromethoxy)-2-fluoroaniline (CAS 1003865-65-3)
- (4-(Difluoromethoxy)-2-fluorophenyl)boronic acid (CAS 1004775-34-1)
- 4,6-Bis(difluoromethoxy)-2-(methylthio)pyrimidine (CAS 100478-25-9)
- 1-(3-(Difluoromethoxy)phenyl)-3-(1,5-dimethyl-1H-pyrazol-4-yl)prop-2-en-1-one (CAS 1005647-45-9)
- Methyl 6-(4-(difluoromethoxy)phenyl)-3-methylisoxazolo[5,4-b]pyridine-4-carboxylate (CAS 1011396-51-2)
Recommended Standards
- 2-Amino-5-(2-(methylthio)ethyl)-1H-imidazol-4(5H)-one (CAS 872784-57-1)
- 3',5'-Dimethyl-1'-(2-methylprop-2-en-1-yl)-1H,1'H-3,4'-bipyrazole-5-carboxylic acid (CAS 890624-75-6)
- 3-(Azetidin-2-yl)propanoic acid (CAS 1784407-42-6)
- Methyl 4-6-O-benzylidene-3-deoxy-α-D-glucopyranoside (CAS 65530-28-1)
- 1,3-Dihydrospiro[indene-2,5'-oxazolidine]-2',4'-dione (CAS 67851-71-2)
- 1,8-Dimethoxynaphthalene (CAS 10075-66-8)
- Ethyl 1-isopropylpiperazine-2-carboxylate (CAS 226068-05-9)
- Ponatinib Impurity 11 (CAS CATO-C4X-226911)
- Chlorine Oxide-18O (CAS 166244-37-7)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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