Azelastine EP Impurity E CAS 20526-97-0
| CAS No. | 20526-97-0 |
| Molecular Formula | C15H9ClO2 |
| Molecular Weight | 256.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 256.68 g/mol gives Azelastine EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Azelastine EP Impurity E (CAS 20526-97-0, C15H9ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system, Azelastine EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Azelastine EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H9ClO2 |
| Molecular Weight | 256.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Azelastine Standards
- Azelastine EP Impurity E (Z-Isomer) (CAS 105279-16-1)
- Azelastine impurity 61 (CAS CATO-C4X-139661)
- Azelastine impurity 53 (CAS CATO-C4X-139653)
- Azelastine EP Impurity B (CAS 110406-94-5)
- Azelastine Impurity 46 (CAS 109386-70-1)
- Azelastine EP Impurity D (CAS 53242-88-9)
- Azelastine Impurity 67 (CAS CATO-C4X-139667)
- Azelastine Impurity 68 (CAS CATO-C4X-139668)
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